Evidence map›Paper›PMID 35088943›Full record

ArticleJournal of cellular and molecular medicine2022

Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions.

Zenglei Zhang, Yanyan Xu, Chang Cao, Bo Wang, Jiacheng Guo, Zhen Qin, Yongzheng Lu, Jianchao Zhang, Li Zhang, Wei Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  14. The Potential of Mesenchymal Stem Cell-Derived Exosomes in Cardiac Repair.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Zenglei ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanyan XuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chang CaoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bo WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jiacheng GuoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhen QinDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yongzheng LuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jianchao ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wei WangHenan Medical Association, Zhengzhou, China.
Jinying ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-5284-2213
Junnan TangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-4340-5337
Henan Energy & Chemical Industry Group (China) · CNChinese Medical Association · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have confirmed that cardiomyocyte-derived exosomes have many pivotal biological functions, like influencing the progress of coronary artery disease via modulating macrophage phenotypes. However, the mechanisms underlying the crosstalk between cardiomyocytes and macrophages have not been fully characterized. Hence, this study aimed to observe the interaction between cardiomyocytes under hypoxia and macrophages through exosome communication and further evaluate the ability of exosomes derived from cardiomyocytes cultured under hypoxic conditions (Hypo-Exo) to polarize macrophages, and the effect of alternatively activated macrophages (M2) on hypoxic cardiomyocytes. Our results revealed that hypoxia facilitated the production of transforming growth factor-beta (TGF-β) in H9c2 cell-derived exosomes. Moreover, exosomes derived from cardiomyocytes cultured under normal conditions (Nor-Exo) and Hypo-Exo could induce RAW264.7 cells into classically activated macrophages (M1) and M2 macrophages respectively. Likewise, macrophage activation was induced by circulating exosomes isolated from normal human controls (hNor-Exo) or patients with acute myocardial infarction (hAMI-Exo). Thus, our findings support that the profiles of hAMI-Exo have been changed, which could regulate the polarization of macrophages and subsequently the polarized M2 macrophages reduced the apoptosis of cardiomyocytes in return. Based on our findings, we speculate that exosomes have emerged as important inflammatory response modulators regulating cardiac oxidative stress injury.

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsHumansHypoxiaMacrophagesMyocytes, CardiacMicroRNAscardiomyocytescell-cell interactionsexosomeshypoxiamacrophage polarization

Identifiers

PMID35088943
PMCPMC8899199
OpenAlexW4210619512

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.