ArticleHuman brain mapping2022
Development of functional organization within the sensorimotor network across the perinatal period.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.Pediatric research · 2026Article
- Global remapping of the sensory homunculus emerges early in childhood development.Nature communications · 2026Article
- Motor performance and higher associative cortical networks in adolescents with neonatal hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia.Developmental medicine and child neurology · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Early Development and Co-Evolution of Microstructural and Functional Brain Connectomes: A Multi-Modal MRI Study in Preterm and Full-Term Infants.Human brain mapping · 2025Article
- The Evolving Cerebellar and Cerebello-cortical Functional Connectivity Architecture during Infancy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Typical and disrupted small-world architecture and regional communication in full-term and preterm infants.PNAS nexus · 2025Article
- Sleep state-dependent development of resting-state functional connectivity during the preterm period.Sleep · 2024Article
- Trajectories of human brain functional connectome maturation across the birth transition.PLoS biology · 2024Article
- Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment.Nature communications · 2024Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Development of functional organization within the sensorimotor network across the perinatal period.Human brain mapping · 2022Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
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Abstract
In the mature human brain, the neural processing related to different body parts is reflected in patterns of functional connectivity, which is strongest between functional homologs in opposite cortical hemispheres. To understand how this organization is first established, we investigated functional connectivity between limb regions in the sensorimotor cortex in 400 preterm and term infants aged across the equivalent period to the third trimester of gestation (32-45 weeks postmenstrual age). Masks were obtained from empirically derived functional responses in neonates from an independent data set. We demonstrate the early presence of a crude but spatially organized functional connectivity, that rapidly matures across the preterm period to achieve an adult-like configuration by the normal time of birth. Specifically, connectivity was strongest between homolog regions, followed by connectivity between adjacent regions (different limbs but same hemisphere) already in the preterm brain, and increased with age. These changes were specific to the sensorimotor network. Crucially, these trajectories were strongly dependent on age more than age of birth. This demonstrates that during the perinatal period the sensorimotor cortex undergoes preprogrammed changes determining the functional movement organization that are not altered by preterm birth in absence of brain injury.
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