ArticleJournal of experimental botany2022
Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
Article in Journal of experimental botany, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 30 citations in OpenAlex.
- Genetic analyses of autoimmune mutants uncover the MPK3/6-CHR5-SNC1 module in Arabidopsis.Scientific reports · 2026Article
- An Evaluation of the Interaction of Brefeldin A with Mitogen-Activated Protein Kinase 1 (MAPK1) and Protein Kinase C Alpha (PrKCα): Insights from Molecular Modelling Studies.International journal of molecular sciences · 2026Article
- Integrated Phenotypic, Physiological, Biochemical, and Transcriptomic Analyses Reveal the Molecular Response Mechanisms ofJournal of fungi (Basel, Switzerland) · 2025Article
- The multifaceted roles of PP2C phosphatases in plant growth, signaling, and responses to abiotic and biotic stresses.Plant communications · 2025Review
- Emerging Functions of Protein Tyrosine Phosphatases in Plants.International journal of molecular sciences · 2024Review
- CaMAPK1 Plays a Vital Role in the Regulation of Resistance toPlants (Basel, Switzerland) · 2024Article
- Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1.Molecular plant pathology · 2024Article
- Insights into the early transcriptomic response against watermelon mosaic virus in melon.BMC plant biology · 2024Article
- VvWRKY5 enhances white rot resistance in grape by promoting the jasmonic acid pathway.Horticulture research · 2023Article
- Genome-wide characterization of theFrontiers in plant science · 2023Article
- Genome-Wide Identification and Expression Analysis of MAPK Gene Family in Lettuce (International journal of molecular sciences · 2022Article
- Opposite roles of MAPKKK17 and MAPKKK21 againstFrontiers in plant science · 2022Article
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Authors and funding
14 authors at 9 institutions in 6 countries.
Funding
Abstract
Mitogen-activated protein kinase (MAPK) cascades transmit environmental signals and induce stress and defence responses in plants. These signalling cascades are negatively controlled by specific Ser/Thr protein phosphatases of the type 2C (PP2C) and dual-specificity phosphatase (DSP) families that inactivate stress-induced MAPKs; however, the interplay between phosphatases of these different types has remained unknown. This work reveals that different Arabidopsis MAPK phosphatases, the PP2C-type AP2C1 and the DSP-type MKP1, exhibit both specific and overlapping functions in plant stress responses. Each single mutant, ap2c1 and mkp1, and the ap2c1 mkp1 double mutant displayed enhanced stress-induced activation of the MAPKs MPK3, MPK4, and MPK6, as well as induction of a set of transcription factors. Moreover, ap2c1 mkp1 double mutants showed an autoimmune-like response, associated with increased levels of the stress hormones salicylic acid and ethylene, and of the phytoalexin camalexin. This phenotype was reduced in the ap2c1 mkp1 mpk3 and ap2c1 mkp1 mpk6 triple mutants, suggesting that the autoimmune-like response is due to MAPK misregulation. We conclude that the evolutionarily distant MAPK phosphatases AP2C1 and MKP1 contribute crucially to the tight control of MAPK activities, ensuring appropriately balanced stress signalling and suppression of autoimmune-like responses during plant growth and development.
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