SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022
Mass Drug Administration for the Control of Scabies: A Systematic Review and Meta-analysis.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Pooled it
- Global prevalence and predictors of scabies among prisoners: systematic review and meta-analysis.BMC public health · 2024Pooled it
- Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial.BMJ (Clinical research ed.) · 2026Trial
- Massive scabies outbreak in Rohingya refugee camps, Cox's Bazar: Epidemiology and impact of a mass drug administration (MDA) campaign - A retrospective study.PLoS neglected tropical diseases · 2026Observational
- Clinical features of 170 Chinese scabies cases and the therapeutic efficacy of sulfur ointment.PLoS neglected tropical diseases · 2026Article
- Assessment of scabies diagnosis and the impact of MDA for onchocerciasis on the burden of scabies in an endemic community in Ghana.BMC infectious diseases · 2026Article
- The Prevalence of Scabies, Skin Infection and Rheumatic Heart Disease in a Cross-Sectional Study of Tongan Primary School Children.Journal of paediatrics and child health · 2026Article
- National control programs for scabies: Experiences from Fiji and Solomon Islands.PLoS neglected tropical diseases · 2026Article
- Tracing the Itch: A Spatiotemporal Analysis of Scabies Rates and Its Risk Factors Using the Global Burden of Disease 2021 Data.Tropical medicine & international health : TM & IH · 2025Article
- An outbreak of scabies in a fishing community in Hoima District, Uganda, February - June, 2022.BMC infectious diseases · 2025Article
- Prevalence of scabies and bacterial skin infection in French Polynesia: A cross-sectional community survey.PLoS neglected tropical diseases · 2025Article
- Assessing the evidence for antibiotic management of laboratory-confirmedIJID regions · 2025Review
- Review of the WHO guideline on preventive chemotherapy for public health control of strongyloidiasis.The Lancet. Infectious diseases · 2025Review
- High caseload of Scabies amongst Rohingya refugees in Cox's Bazar, Bangladesh: A retrospective analysis of the epidemiological and clinical characteristics of cases, July 2022 to November 2023.PLOS global public health · 2025Article
- Detecting spatial clusters of human scabies in Tigray, Ethiopia from 2018 to 2023.BMC infectious diseases · 2024Article
- Scabies.Nature reviews. Disease primers · 2024Review
- Ivermectin-Based Mass Drug Administration for Scabies in Northern India: A Single-Arm Community Intervention Trial.Open forum infectious diseases · 2024Article
- Modelling mass drug administration strategies for reducing scabies burden in Monrovia, Liberia.Epidemiology and infection · 2023Article
- Scabies prevalence after ivermectin-based mass drug administration for lymphatic filariasis, Samoa 2018-2019.PLoS neglected tropical diseases · 2023Article
- Factors influencing community acceptability of mass drug administration for the elimination of onchocerciasis in the Asante Akim South Municipal, Ghana.PLoS neglected tropical diseases · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScabies is a neglected tropical disease of the skin that can lead to impetigo, serious secondary bacterial infections and immune-mediated diseases. Mass drug administration (MDA) has been reported in several studies to reduce the prevalence of scabies and impetigo. We aimed to assess the efficacy of MDA for scabies on scabies and impetigo.
methodsWe conducted a systematic review and meta-analysis of reports on the impact of MDA on scabies and impetigo. We included randomized control trials and observational evaluations reported from January 1970 to April 2021 and involving human participants. We searched PubMed, Ovid Medline, Embase, and Cochrane. We considered MDA as treatment intended for the whole population, regardless of individual infection status or symptoms. The main outcome assessed was the change in scabies and impetigo prevalence following MDA. This review is registered with PROSPERO (CRD42020169839).
resultsWe identified 1110 records, of which 11 met inclusion criteria for the review and 9 were deemed suitable for meta-analysis for scabies and 4 for impetigo. Most studies were in small populations. There was a high degree of heterogeneity between studies (I2 value 96.19%). The overall relative reduction of the impact of MDA on scabies prevalence was 79%. The effect size was comparable for MDA based on ivermectin and permethrin. MDA for scabies also led to a reduction in impetigo prevalence with a relative reduction of 66%.
conclusionsMDA for scabies is highly effective in reducing the prevalence of scabies and impetigo. Further research is needed to determine the durability of impact, and the effectiveness of MDA regimens in larger populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.