Evidence map›Paper›PMID 35088712›Full record

ArticleeLife2022

Paraxial mesoderm organoids model development of human somites.

Christoph Budjan, Shichen Liu, Adrian Ranga, Senjuti Gayen, Olivier Pourquié, Sahand Hormoz

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Three-dimensional stem cell models of mammalian gastrulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christoph BudjanDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-1563-9750
Shichen LiuDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-0964-6559
Adrian RangaLaboratory of Bioengineering and Morphogenesis, Biomechanics Section, Department of Mechanical Engineering, Leuven, Belgium.ORCID 0000-0002-6400-9472
Senjuti GayenDepartment of Systems Biology, Harvard Medical School, Boston, United States.
Olivier PourquiéDepartment of Genetics, Harvard Medical School, Boston, United States.
Sahand HormozDepartment of Systems Biology, Harvard Medical School, Boston, United States.ORCID 0000-0002-4384-4428
Harvard University · USBrigham and Women's Hospital · USBroad Institute · US

Funding

Regulatory Roles and Dynamics of Nuclear long-noncoding RNAs in PluripotencyP01GM099117 · NIGMS · HARVARD UNIVERSITY · PI MEISSNER, ALEXANDER · 2011 to 2021
$21.2M
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasmsR01HL158269 · NHLBI · DANA-FARBER CANCER INST · PI HORMOZ, SAHAND · 2021 to 2025
$2.3M
NHLBI NIH HHS R01 HL158269NIGMS NIH HHS P01 GM099117
6 · The paper itself

Abstract

During the development of the vertebrate embryo, segmented structures called somites are periodically formed from the presomitic mesoderm (PSM) and give rise to the vertebral column. While somite formation has been studied in several animal models, it is less clear how well this process is conserved in humans. Recent progress has made it possible to study aspects of human paraxial mesoderm (PM) development such as the human segmentation clock

Indexed as

Pluripotent Stem CellsSomitesAnimalsCell DifferentiationHumansMesodermOrganoidsdevelopmental biologyhumanhuman organoidsimage-based screenparaxial mesodermregenerative medicinesomitogenesisstem cells

Identifiers

PMID35088712
PMCPMC8906808
OpenAlexW4220790410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.