Evidence map›Paper›PMID 35088709›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

Aneurysm size and blood pressure severity in patients with intracranial aneurysms and sleep apnea.

Sebastian Zaremba, Luca Albus, Alexis Hadjiathanasiou, Hartmut Vatter, Ullrich Wüllner, Erdem Güresir

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02880059 (Incidence and Effects of Sleep Apnea on Intracerebral Aneurysms - IESA-Study), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02880059 unknown statusnot on this map

Incidence and Effects of Sleep Apnea on Intracerebral Aneurysms - IESA-Study

TypeobservationalSponsorUniversity Hospital, BonnRan2016 to 2021Enrolled200ConditionsSleep Apnea (Defined as Apnea Hypopnea Index > 5/h), Intracranial Aneurysm Size, Blood Pressure Medication, ComorbiditiesArmsCardiorepiratory Polygraphy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sebastian ZarembaDepartment of Neurology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Luca AlbusDepartment of Neurology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Alexis HadjiathanasiouDepartment of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Hartmut VatterDepartment of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Ullrich WüllnerDepartment of Neurology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
Erdem GüresirDepartment of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.
University of Bonn · DEKlinik für Schlafmedizin · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea is a risk factor for hypertension. Hypertension is associated with aneurysm formation, growth, and rupture of intracranial aneurysm (IA). Retrospectively, symptoms of obstructive sleep apnea are more prevalent in patients with IAs. Studies investigating the prevalence and effect of objectively measured sleep apnea in these patients are sparse. We report on the baseline data of an ongoing prospective study. We cross-sectionally analyzed whether obstructive sleep apnea was associated with larger IAs and increased need for antihypertensive medications in a population of patients with unruptured IA.

methods130 adult (≥ 18 years) patients with unruptured IAs were recruited. Patients with ischemic stroke or intracranial hemorrhage within 3 months prior to screening were excluded. We assessed obstructive sleep apnea by full-night respiratory polygraphy. Aneurysm size and antihypertensive medication-as a surrogate parameter for the severity of hypertension-were compared between patients with and without obstructive sleep apnea (apnea-hypopnea index >5 events/h). Aneurysm growth and rupture rate were retrospectively analyzed.

results101 patients completed the study protocol. Obstructive sleep apnea was diagnosed in 68.0% (17) of male and 34.2% (26) of female participants and associated with more severe hypertension (1.536 ± 0.2 vs 0.74 ± 0.1 drugs;

conclusionsPatients with obstructive sleep apnea had more antihypertensive medication and larger IAs, probably due to accelerated aneurysm growth. Sleep apnea should be considered in patients with IAs. More research is needed to investigate the effects of sleep apnea on IAs and aneurysm outcome. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Incidence and Effects of Sleep Apnea on Intracerebral Aneurysms-IESA Study; URL: https://clinicaltrials.gov/ct2/show/NCT02880059; Identifier: NCT02880059. CITATION: Zaremba S, Albus L, Hadjiathanasiou A, Vatter H, Wüllner U, Güresir E. Aneurysm size and blood pressure severity in patients with intracranial aneurysms and sleep apnea.

Indexed as

HypertensionIntracranial AneurysmSleep Apnea, ObstructiveSleep Apnea SyndromesAdultAntihypertensive AgentsBlood PressureFemaleHumansMaleProspective StudiesRetrospective StudiesAntihypertensive Agentshypertensionintracranial aneurysmsleep apnea

Identifiers

PMID35088709
PMCPMC9163607
OpenAlexW4210370431

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.