Evidence map›Paper›PMID 35088395›Full record

ArticleThrombosis and haemostasis2022

DOAC Dipstick Testing Can Reliably Exclude the Presence of Clinically Relevant DOAC Concentrations in Circulation.

Sandra Margetić, Ivana Ćelap, Arijana Lovrenčić Huzjan, Marijana Bosnar Puretić, Sandra Šupraha Goreta, Anesa Čajević Glojnarić, Diana Delić Brkljačić, Pavao Mioč, Job Harenberg, Svetlana Hetjens and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Viscoelastic monitoring of direct oral anticoagulants (DOAC).Blood transfusion = Trasfusione del sangue · 2025
    Article
  8. Direct oral anticoagulants measurement: when is it necessary?Blood transfusion = Trasfusione del sangue · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Challenges to Laboratory Monitoring of Direct Oral Anticoagulants.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
  14. Comparison of the DOAC Dipstick Test on Urine Samples With Chromogenic Substrate Methods on Plasma Samples in Outpatients Treated With Direct Oral Anticoagulants.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Observational
  15. Can We Improve on the Rapid Assessment of Clinically Relevant Levels of Direct Acting Oral Anticoagulants (DOAC)?Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sandra MargetićDepartment of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Ivana ĆelapDepartment of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Arijana Lovrenčić HuzjanDepartment of Neurology, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Marijana Bosnar PuretićDepartment of Neurology, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Sandra Šupraha GoretaFaculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Anesa Čajević GlojnarićDepartment of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Diana Delić BrkljačićDepartment of Cardiovascular Diseases, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Pavao MiočDepartment of Cardiovascular Diseases, Sestre Milosrdnice University Hospital Center, Zagreb County, Croatia.
Job HarenbergDOASENSE GmbH, Heidelberg, Germany.
Svetlana HetjensDepartment of Medical Statistics and Biomathematics, University of Heidelberg Medical Faculty Mannheim, Heidelberg, Germany.
Christel WeissDepartment of Medical Statistics and Biomathematics, University of Heidelberg Medical Faculty Mannheim, Heidelberg, Germany.
Heidelberg University · DEUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present. We examined whether qualitative testing of DOACs in urine samples can exclude DOAC plasma concentrations of ≥30 ng/mL. This prospective single-center cohort study included consecutive patients treated with an oral direct factor Xa inhibitor (DXI) (apixaban,

Indexed as

PyridonesRivaroxabanAdministration, OralAgedAnticoagulantsAntithrombinsCohort StudiesDabigatranFactor Xa InhibitorsFemaleHumansProspective StudiesAnticoagulantsAntithrombinsDabigatranFactor Xa InhibitorsPyridonesRivaroxaban

Identifiers

PMID35088395
PMCPMC9420550
OpenAlexW4210397763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.