SynthesisBrain imaging and behavior2022
Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses.
Synthesis in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in late-life depression: a meta-analysis of resting-state functional imaging studies.Translational psychiatry · 2026Pooled it
- Disrupted and reorganized connectivity of brain networks in multiple sclerosis: a systematic review and meta-analysis of resting-state functional MRI.Journal of neurology · 2026Pooled it
- Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study.Translational psychiatry · 2025Pooled it
- The research progress on effective connectivity in adolescent depression based on resting-state fMRI.Frontiers in neurology · 2025Pooled it
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder.Frontiers in psychiatry · 2026Article
- Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder.Frontiers in psychiatry · 2026Article
- Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment.Frontiers in aging neuroscience · 2026Article
- Regional and interregional brain functional abnormalities in major depressive disorder with childhood maltreatment.BMC psychiatry · 2025Article
- Electroencephalogram Gamma Band Power Correlates with Anhedonia in a Community Sample.Journal of personalized medicine · 2025Article
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder.Scientific reports · 2025Article
- Molecular Link Between Psoriasis and Depression-Update on Pathophysiology.International journal of molecular sciences · 2025Review
- Prefrontal activation in bipolar and unipolar depression patients in the letter fluency tasks and category fluency tasks: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2025Article
- Self-consciousness negatively mediates the positive association between internalized weight bias and weight status in cross-cultural survey and brain imaging study.Frontiers in psychiatry · 2025Article
- Depicting Coupling Between Cortical Morphology and Functional Networks in Major Depressive Disorder.Depression and anxiety · 2025Article
- Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.Brain communications · 2025Article
- Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group.Human brain mapping · 2025Article
- Individualized identification value of stress-related network structural-functional properties and HPA axis reactivity for subthreshold depression.Translational psychiatry · 2024Article
- Negative family and interpersonal relationship are associated with centromedial amygdala functional connectivity alterations in adolescent depression.European child & adolescent psychiatry · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Disrupted whole-brain resting-state functional connectivity (RSFC) of the posterior cingulate (PCC) has been highlighted to associate with cognitive and affective dysfunction in major depressive disorder (MDD). However, prior findings showed certain inconsistency about the RSFC of the PCC in MDD. This study aims to investigate the aberrant RSFC of the PCC in MDD using anisotropic effect-size version of seed-based d mapping (AES-SDM). Web of Science and PubMed were searched for studies investigating PCC-based RSFC in MDD. A total of 17 studies, involving 804 patients and 724 healthy controls (HCs), fit our selection criteria. Additionally, to seek for the link between functional and structural differences, we did a meta-analysis on the studies in conjunction with voxel-based morphology (VBM) analysis. The PCC showed higher RSFC with the left middle temporal gyrus (MTG) and the right middle frontal gyrus (MFG), and lower RSFC with the left superior frontal gyrus (SFG) and the left precuneus in patients with MDD than HCs. Moreover, the meta-regression analysis revealed a negative correlation between the FC alteration of the right MFG with the PCC and depression severity. Notably, the left MTG and the left MFG demonstrated gray matter deviations in conjunction analysis. Our results indicated that the aberrant RSFC between the PCC and brain regions sub-serving cognitive control and emotional regulation in patients with MDD. And such functional alterations may have structural basis. These findings may underlie the mechanisms of deficits in cognitive control and emotional regulation of MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.