ArticleIrish journal of medical science2022
The interplay of long noncoding RNA HULC with microRNA-128-3p and their correlations with lipid level, stenosis degree, inflammatory cytokines, and cell adhesion molecules in coronary heart disease patients.
Article in Irish journal of medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- MiR-128-3p serves as a diagnostic biomarker in pediatric Mycoplasma pneumoniae pneumonia.BMC pulmonary medicine · 2026Article
- Impact of microRNAs on cardiovascular diseases and aging.The Journal of international medical research · 2024Review
- Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course.Non-coding RNA research · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong noncoding RNA HULC (lnc-HULC) and its target microRNA-128-3p (miR-128-3p) regulate endothelial cell function, blood lipid level, and inflammatory cytokine production, which are involved in the pathogenesis of coronary heart disease (CHD). Based on the above information, this study intended to further investigate the correlation between lnc-HULC and miR-128-3p, as well as their clinical values for CHD management.
methodsTotally, 141 CHD patients and 70 controls were enrolled. Lnc-HULC and miR-128-3p in peripheral blood mononuclear cells were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Serum inflammatory cytokines and cell adhesion molecules were further determined by enzyme-linked immunosorbent assay (ELISA) in CHD patients.
resultsLnc-HULC was upregulated, while miR-128-3p was downregulated in CHD patients than in controls (both P < 0.001). The ROC curve further displayed that lnc-HULC (AUC: 0.906, 95% CI: 0.867-0.945) and miR-128-3p (AUC: 0.814, 95% CI: 0.756-0.873) had the potential of discriminating CHD patients from controls. Regarding the correlation between lnc-HULC and miR-128-3p, lnc-HULC was negatively associated with miR-128-3p in CHD patients (r
conclusionLnc-HULC and its target miR-128-3p relate to lipid level, stenosis degree, inflammatory cytokines, and cell adhesion molecules in CHD patients.
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