ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2022
Red-Beet Betalain Pigments Inhibit Amyloid-β Aggregation and Toxicity in Amyloid-β Expressing Caenorhabditis elegans.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- A cyclo-DOPA 6-O-glucosyltransferase-mediated route for gomphrenin I biosynthesis in Basella alba and Gomphrena globosa.The New phytologist · 2026Article
- Four Undescribed Chromane-Type Meroterpenoids From Sargassum siliquastrum and Their Inhibitory Activity Against Amyloid-β42 Aggregation.Chemistry & biodiversity · 2026Article
- Beyond Amyloids: Neuroprotective Potential of Betanin and its Derivatives Against Alpha-Synuclein Aggregates and ROS Overload in Parkinson's Disease.Journal of molecular neuroscience : MN · 2026Article
- New meroterpenoids from Sargassum macrocarpum as inhibitors of amyloid β aggregation.Journal of natural medicines · 2026Article
- Neuroprotective Effects of Betanin in a Mouse Model of Parkinson's Disease: Behavioural and Neurotransmitter Pathway Insights.International journal of molecular sciences · 2025Article
- Identification ofPlant biotechnology (Tokyo, Japan) · 2025Article
- The Neuroprotective Potential of Betalains: A Focused Review.Plants (Basel, Switzerland) · 2025Review
- Identification of R2R3-MYB Transcription Factor Family Based onPlants (Basel, Switzerland) · 2025Article
- Red beet betalains extraction process: A comprehensive review of methods, applications, and physicochemical properties.Food science & nutrition · 2024Review
- Protective effects of betanin, a novel acetylcholinesterase inhibitor, against HMolecular biology reports · 2024Article
- Article
- Anti-Amyloid β Aggregation Activity and Cell Viability Effect of Betacyanins from Red Pitahaya (Hylocereus polyrhizus) for Alzheimer's Disease.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Article
- Effects of heat degradation of betanin in red beetroot (Beta vulgaris L.) on biological activity and antioxidant capacity.PloS one · 2023Article
- Natural Bioactive Products and Alzheimer's Disease Pathology: Lessons fromDiseases (Basel, Switzerland) · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Betalain pigments are mainly produced by plants belonging to the order of Caryophyllales. Betalains exhibit strong antioxidant activity and responds to environmental stimuli and stress in plants. Recent reports of antioxidant, anti-inflammatory and anti-cancer properties of betalain pigments have piqued interest in understanding their biological functions. We investigated the effects of betalain pigments (betanin and isobetanin) derived from red-beet on amyloid-β (Aβ) aggregation, which causes Alzheimer's disease. Non-specific inhibition of Aβ aggregation against Aβ40 and Aβ42 by red-beet betalain pigments, in vitro was demonstrated using the thioflavin t fluorescence assay, circular dichroism spectroscopy analysis, transmission electron microscopy and nuclear magnetic resonance (NMR) analysis. Furthermore, we examined the ability of red-beet betalain pigments to interfere with Aβ toxicity by using the transgenic Caenorhabditis elegans model, which expresses the human Aβ42 protein intracellularly within the body wall muscle. It responds to Aβ-toxicity with paralysis and treatment with 50 μM red-beet betalain pigments significantly delayed the paralysis of C. elegans. These results suggest that betalain pigments reduce Aβ-induced toxicity.
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