ReviewBioactive materials2022
Potential bioactive coating system for high-performance absorbable magnesium bone implants.
Review in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 99 citations in OpenAlex.
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Prospective Pilot Clinical Study of High-Purity Magnesium Plates and Screws for Le Fort I Osteosynthesis.International dental journal · 2026Article
- Biodegradable Metals and Corrosion Control: Challenges, Limits and New Opportunities for Innovating in Orthopedic Fixations.Materials (Basel, Switzerland) · 2026Review
- Biodegradable magnesium-calcium mineralized collagen metal materials inhibits invasion and metastasis of osteosarcoma.Scientific reports · 2025Article
- Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment.Bioactive materials · 2025Article
- Versatile application of magnesium-related bone implants in the treatment of bone defects.Materials today. Bio · 2025Review
- Metal-Based Regenerative Strategies for Peripheral Nerve Injuries: From Biodegradable Ion Source to Stable Conductive Implants.Biomaterials research · 2025Review
- Research progress on the role and mechanism of magnesium-containing materials in bone repair.Biomaterials translational · 2025Review
- Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis.Journal of orthopaedic translation · 2025Article
- Article
- Metal semiconductor materials in bone diseases: properties, applications, and future perspectives.Burns & trauma · 2025Review
- A biodegradable magnesium phosphate cement incorporating chitosan and rhBMP-2 designed for bone defect repair.Journal of orthopaedic translation · 2024Article
- Treatment of osteoarthritis by implantation of Mg- and WE43-cylinders - A preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits.Bioactive materials · 2024Article
- Influence of Noble Metals on Morphology and Topology of Structural Elements in Magnesium Alloy.Materials (Basel, Switzerland) · 2024Article
- Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Review
- Advances in magnesium-containing bioceramics for bone repair.Biomaterials translational · 2024Review
- Forged to heal: The role of metallic cellular solids in bone tissue engineering.Materials today. Bio · 2023Article
- Article
- In vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing.Bioactive materials · 2023Article
- A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants.Bioactive materials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture. In this review, a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process. The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction. Hydroxyapatite, collagen type I, recombinant human bone morphogenetic proteins 2, simvastatin, zoledronate, and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants. In addition to coating, the substrate itself can be made bioactive by alloying magnesium with calcium, zinc, copper, and manganese that were found to promote bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.