Evidence map›Paper›PMID 35087959›Full record

ArticleBioactive materials2022

Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment.

Libin Pang, Renliang Zhao, Jing Chen, Jingxin Ding, Xiaochen Chen, Wenwen Chai, Xu Cui, Xiaolin Li, Deping Wang, Haobo Pan

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. PtTeMaterials today. Bio · 2026
    Article
  3. Article
  4. Review
  5. How Emerging Nanomaterials are Effective in Bone Regeneration?International journal of nanomedicine · 2026
    Review
  6. Article
  7. Review
  8. Advancing Nanomedicine: For Bone Defect Repair and Regeneration.International journal of nanomedicine · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Design andNanomedicine (London, England) · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Diphasic CeOBiomaterials research · 2024
    Article
  18. Sol-gel derived BRegenerative biomaterials · 2024
    Article
  19. Review
  20. Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Libin PangSchool of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Renliang ZhaoDepartment of Orthopedic Surgery, and Shanghai Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Jing ChenShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jingxin DingSchool of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Xiaochen ChenSchool of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Wenwen ChaiSchool of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Xu CuiShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiaolin LiDepartment of Orthopedic Surgery, and Shanghai Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Deping WangSchool of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.
Haobo PanShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Tongji University · CNChinese Academy of Sciences · CNShanghai Jiao Tong University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical bone defects caused by extensive excision of malignant bone tumor and the probability of tumor recurrence due to residual tumor cells make malignant bone tumor treatment a major clinical challenge. The present therapeutic strategy concentrates on implanting bone substitutes for defect filling but suffers from failures in both enhancing bone regeneration and inhibiting the growth of tumor cells. Herein, Cu and Mn-doped borosilicate nanoparticles (BSNs) were developed for syncretic bone repairing and anti-tumor treatment, which can enhance bone regeneration through the osteogenic effects of Cu

Indexed as

Bio-ceramicsBone regenerationBone tumor treatmentBorosilicateChemodynamic therapyTumor therapy

Identifiers

PMID35087959
PMCPMC8777258
OpenAlexW3210457895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.