Evidence map›Paper›PMID 35087953›Full record

ArticleBiology methods & protocols2022

Improving one-step scarless genome editing in

Katharina J Götze, Achmed Mrestani, Paula Beckmann, Knut Krohn, Diana Le Duc, Akhil Velluva, Mathias A Böhme, Manfred Heckmann, Rami Abou Jamra, Johannes R Lemke and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology methods & protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Single nucleotide variants inBiochemistry and biophysics reports · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Katharina J GötzeRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.
Achmed MrestaniRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-3063-164X
Paula BeckmannRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.
Knut KrohnCore Unit DNA, Medical Faculty, University of Leipzig Medical Center, Leipzig 04103, Germany.
Diana Le DucInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0001-7289-2552
Akhil VelluvaInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig 04103, Germany.
Mathias A BöhmeRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.
Manfred HeckmannInstitute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg 97070, Germany.
Rami Abou JamraInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig 04103, Germany.
Johannes R LemkeInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-4435-6610
Hendrik BläkerInstitute of Pathology, University of Leipzig Medical Center, Leipzig 04103, Germany.
Nicole ScholzRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0001-8087-8451
Dmitrij LjaschenkoRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.
Tobias LangenhanRudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-9061-3809
Leipzig University · DEUniversity of Würzburg · DEMax Planck Institute for Evolutionary Anthropology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise and rapid construction of alleles through CRISPR/Cas9-mediated genome engineering renders

Indexed as

armadillocancerCas9CRISPRDrosophilagenome engineeringMunc13neurodevelopmental disordersynapse

Identifiers

PMID35087953
PMCPMC8789338
OpenAlexW4206834695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.