ReviewFrontiers in molecular biosciences2021
GDP-Mannose 3,5-Epimerase: A View on Structure, Mechanism, and Industrial Potential.
Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 23 citations in OpenAlex.
- Kinetic Dissection of the Reaction of Human GDP-l-Fucose Synthase.ACS catalysis · 2025Article
- Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress.BMC plant biology · 2025Article
- Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase.Computational and structural biotechnology journal · 2025Article
- Physiological and Proteomic Analysis of Various Priming on Rice Seed under Chilling Stress.Plants (Basel, Switzerland) · 2024Article
- The ascorbate biosynthesis pathway in plants is known, but there is a way to go with understanding control and functions.Journal of experimental botany · 2024Review
- A mutation in CsGME encoding GDP-mannose 3,5-epimerase results in little and wrinkled leaf in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Article
- Effect of light on ascorbic acid biosynthesis and bioinformatics analysis of related genes in Chinese chives.PloS one · 2024Article
- Research overview on the genetic mechanism underlying the biosynthesis of polysaccharide in tuber plants.PeerJ · 2024Review
- Comparative Metabolomic and Transcriptomic Analyses Reveal Distinct Ascorbic Acid (AsA) Accumulation Patterns between PCA and PCNA Persimmon Developing Fruit.International journal of molecular sciences · 2023Article
- Review
- Molecular cloning and functional analysis of a Chrysanthemum vestitum GME homolog that enhances drought tolerance in transgenic tobacco.Scientific reports · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GDP-mannose 3,5-epimerase (GM35E, GME) belongs to the short-chain dehydrogenase/reductase (SDR) protein superfamily and catalyses the conversion of GDP-d-mannose towards GDP-l-galactose. Although the overall reaction seems relatively simple (a double epimerization), the enzyme needs to orchestrate a complex set of chemical reactions, with no less than 6 catalysis steps (oxidation, 2x deprotonation, 2x protonation and reduction), to perform the double epimerization of GDP-mannose to GDP-l-galactose. The enzyme is involved in the biosynthesis of vitamin C in plants and lipopolysaccharide synthesis in bacteria. In this review, we provide a clear overview of these interesting epimerases, including the latest findings such as the recently characterized bacterial and thermostable GM35E representative and its mechanism revision but also focus on their industrial potential in rare sugar synthesis and glycorandomization.
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