Evidence map›Paper›PMID 35087270›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

The Development of a COPD Exacerbation Recognition Tool (CERT) to Help Patients Recognize When to Seek Medical Advice.

Paul W Jones, Chanzheng Wang, Ping Chen, Liping Chen, Daoxin Wang, Junbo Xia, Yang Yang, Yingyu Wang, Qianli Ma

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Article
  8. Review
  9. Early detection and prediction of acute exacerbation of chronic obstructive pulmonary disease.Chinese medical journal pulmonary and critical care medicine · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul W JonesGlobal Medical, Regulatory and Quality, GlaxoSmithKline plc., Brentford, UK.ORCID 0000-0001-6087-9182
Chanzheng WangRespiratory Department, Chongqing Xinqiao Hospital, Chongqing, People's Republic of China.
Ping ChenRespiratory Department, General Hospital of the Northern Theater Command of the People's Liberation Army, Shenyang, People's Republic of China.
Liping ChenRespiratory Department, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, People's Republic of China.
Daoxin WangRespiratory Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Junbo XiaRespiratory Department, Hangzhou First People's Hospital, Hangzhou, Zhejiang, People's Republic of China.
Yang YangResearch and Development, GlaxoSmithKline plc., Shanghai, People's Republic of China.
Yingyu WangResearch and Development, GlaxoSmithKline plc., Shanghai, People's Republic of China.
Qianli MaRespiratory Department, Chongqing Xinqiao Hospital, Chongqing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany patients with chronic obstructive pulmonary disease (COPD) do not report exacerbations and may benefit from simple guidance about when to seek medical attention, so we developed a COPD Exacerbation Recognition Tool (CERT).

methodsThe study was run across three sites in China in patients who had an exacerbation within the previous year. Step 1: focus group qualitative study (total 48 patients) captured symptoms associated with an exacerbation. Step 2: cognitive debriefing to ensure items were appropriately worded. Step 3: 150 patients (69 years, 21% female, FEV

resultsFollowing Steps 1 and 2, 29 candidate items were selected for Step 3. Response rates with the two response options were very similar. There was minimal influence of demographic factors on response to the items. EFA using the 11 items with the highest response rates identified two principal factors, Factor 1: breathlessness and activity limitation (79.1% of variance), Factor 2: cough and sputum (20.9% of variance). Five items were selected for the CERT based on response rate and EFA factor loading: worsening cough, increased sputum volume, shortness of breath, laborious breathing, and limitation of motion. Sensitivity analysis suggested that worsening of two or more symptoms had good sensitivity and specificity for the presence of an exacerbation. DISCUSSION: The CERT is an evidence-based tool to provide patients with simple-to-follow guidance about when to seek medical attention when their COPD symptoms worsen.

Indexed as

Pulmonary Disease, Chronic ObstructiveDisease ProgressionFemaleHumansMaleRespiratory Function TestsSputumSurveys and Questionnaireschronic obstructive pulmonary diseaseCOPD exacerbation toolexacerbations

Identifiers

PMID35087270
PMCPMC8789323

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.