Evidence map›Paper›PMID 35087182›Full record

ArticleNPJ digital medicine2022

Predictive structured-unstructured interactions in EHR models: A case study of suicide prediction.

Ilkin Bayramli, Victor Castro, Yuval Barak-Corren, Emily M Madsen, Matthew K Nock, Jordan W Smoller, Ben Y Reis

Abstract read
In one paragraph

Article in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Life events extraction from healthcare notes for veteran acute suicide risk prediction.Journal of the American Medical Informatics Association : JAMIA · 2026
    Article
  2. Article
  3. Using transfer learning to improve prediction of suicide risk in acute care hospitals.Journal of the American Medical Informatics Association : JAMIA · 2026
    Article
  4. Prediction of neoadjuvant chemotherapy efficacy in patients with HER2-low breast cancer based on ultrasound radiomics.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilkin BayramliPredictive Medicine Group, Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
Victor CastroMass General Brigham Research Information Science and Computing, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7390-6354
Yuval Barak-CorrenPredictive Medicine Group, Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9603-4728
Emily M MadsenPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Matthew K NockDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Jordan W Smoller *Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Ben Y Reis *Predictive Medicine Group, Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA. ben_reis@harvard.edu.ORCID http://orcid.org/0000-0001-9908-5523

Funding

Improved multifactorial prediction of suicidal behavior through integration of multiple datasetsR01MH117599 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI REIS, BEN Y, SMOLLER, JORDAN W · 2018 to 2021
$2.1M
NIMH NIH HHS R01 MH117599U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH117599
6 · The paper itself

Abstract

Clinical risk prediction models powered by electronic health records (EHRs) are becoming increasingly widespread in clinical practice. With suicide-related mortality rates rising in recent years, it is becoming increasingly urgent to understand, predict, and prevent suicidal behavior. Here, we compare the predictive value of structured and unstructured EHR data for predicting suicide risk. We find that Naive Bayes Classifier (NBC) and Random Forest (RF) models trained on structured EHR data perform better than those based on unstructured EHR data. An NBC model trained on both structured and unstructured data yields similar performance (AUC = 0.743) to an NBC model trained on structured data alone (0.742, p = 0.668), while an RF model trained on both data types yields significantly better results (AUC = 0.903) than an RF model trained on structured data alone (0.887, p < 0.001), likely due to the RF model's ability to capture interactions between the two data types. To investigate these interactions, we propose and implement a general framework for identifying specific structured-unstructured feature pairs whose interactions differ between case and non-case cohorts, and thus have the potential to improve predictive performance and increase understanding of clinical risk. We find that such feature pairs tend to capture heterogeneous pairs of general concepts, rather than homogeneous pairs of specific concepts. These findings and this framework can be used to improve current and future EHR-based clinical modeling efforts.

Identifiers

PMID35087182
PMCPMC8795240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.