Evidence map›Paper›PMID 35087161›Full record

ArticleScientific reports2022

Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease.

Henok Kessete Afewerky, Hao Li, Tongmei Zhang, Xinyan Li, Yacoubou Abdoul Razak Mahaman, Limin Duan, Pengwei Qin, Jiequn Zheng, Lei Pei, Youming Lu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  4. Article
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  6. Article
  7. Preclinical Evidence ofInternational journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Antioxidants (Basel, Switzerland) · 2024
    Article
  11. Plants (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Henok Kessete AfewerkyDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. henokessete@hust.edu.cn.
Hao LiThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Tongmei ZhangThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Xinyan LiThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Yacoubou Abdoul Razak MahamanDepartment of Pathology and Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Limin DuanThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Pengwei QinThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Jiequn ZhengThe Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Lei PeiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Youming LuDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lym@hust.edu.cn.
Huazhong University of Science and Technology · CNUniversity of Asmara · ER

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The third isoform of the Na

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitionDisease Models, AnimalMice, TransgenicPlant ExtractsSodium-Calcium ExchangerWithaniaAnimalsMaleMicePlant RootsAmyloid beta-PeptidesPlant ExtractsSlc8a3 protein, mouseSodium-Calcium Exchanger

Identifiers

PMID35087161
PMCPMC8795410
OpenAlexW4210496123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.