ArticleScientific reports2022
Effects of working memory load on frontal connectivity in children with autism spectrum disorder: a fNIRS study.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Cortical Region Reporting Patterns in Neurodevelopmental Disorders: A Systematic Review of fNIRS Studies.Biosensors · 2026Pooled it
- Left frontal activity measured by fNIRS during a verbal memory task is modulated by predictability in cognitively healthy older adults.Neuroimage. Reports · 2026Article
- Reduced intra-frontal functional connectivity during a verbal fluency task in depressed individuals with autistic traits: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Prefrontal Blood Flow Activity During Drawing Intervention in School-Age Children with Autism: An fNIRS Hyperscanning Study.Brain sciences · 2025Article
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- Article
- Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis.Brain imaging and behavior · 2024Article
- From functional neuroimaging to neurostimulation: fNIRS devices as cognitive enhancers.Behavior research methods · 2024Article
- Functional near-infrared spectroscopy in elderly patients with four types of dementia.World journal of psychiatry · 2023Article
- Aberrant prefrontal functional connectivity during verbal fluency test is associated with reading comprehension deficits in autism spectrum disorder: An fNIRS study.Frontiers in psychology · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with autism spectrum disorder (ASD) perform poorly in working memory (WM) tasks, with some literature suggesting that their impaired performance is modulated by WM load. While some neuroimaging and neurophysiological studies have reported altered functional connectivity during WM processing in individuals with autism, it remains largely unclear whether such alterations are moderated by WM load. The present study aimed to examine the effect of WM load on functional connectivity within the prefrontal cortex (PFC) in ASD using functional near-infrared spectroscopy (fNIRS). Twenty-two children with high-functioning ASD aged 8-12 years and 24 age-, intelligent quotient (IQ)-, sex- and handedness-matched typically developing (TD) children performed a number n-back task with three WM loads (0-back, 1-back, and 2-back). Hemodynamic changes in the bilateral lateral and medial PFC during task performance were monitored using a multichannel NIRS device. Children with ASD demonstrated slower reaction times, specifically during the "low load" condition, than TD children. In addition, the ASD and TD groups exhibited differential load-dependent functional connectivity changes in the lateral and medial PFC of the right but not the left hemisphere. These findings indicate that WM impairment in high-functioning ASD is paralleled by load-dependent alterations in right, but not left, intrahemispheric connectivity during WM processing in children with ASD. A disruption of functional neural connections that support different cognitive processes may underlie poor performance in WM tasks in ASD.
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