Evidence map›Paper›PMID 35087103›Full record

ArticleScientific reports2022

Noncanonical function of the Sex lethal gene controls the protogyny phenotype in Drosophila melanogaster.

Ki-Hyeon Seong, Siu Kang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ki-Hyeon SeongRIKEN Cluster for Pioneering Research, RIKEN Tsukuba Institute, Tsukuba, Ibaraki, Japan. ki-hyeon.seong@riken.jp.
Siu KangGraduate School of Science and Engineering, Yamagata University, Jonan, Yonezawa, Yamagata, Japan.
Japan Agency for Medical Research and Development · JPPioneer (Japan) · JP

Funding

Japan Agency for Medical Research and Development JP18gm1110001
6 · The paper itself

Abstract

Drosophila melanogaster females eclose on average 4 h faster than males owing to sexual differences in the pupal period, referred to as the protogyny phenotype. Here, to elucidate the mechanism underlying the protogyny phenotype, we used our newly developed Drosophila Individual Activity Monitoring and Detecting System (DIAMonDS) that detects the precise timing of both pupariation and eclosion in individual flies. Although sex transformation induced by tra-2, tra alteration, or msl-2 knockdown-mediated disruption of dosage compensation showed no effect on the protogyny phenotype, stage-specific whole-body knockdown and mutation of the Drosophila master sex switch gene, Sxl, was found to disrupt the protogyny phenotype. Thus, Sxl establishes the protogyny phenotype through a noncanonical pathway in D. melanogaster.

Indexed as

Sex Determination ProcessesAnimalsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesMalePhenotypePupaRibonucleoproteinsRNA-Binding ProteinsTranscription FactorsDNA-Binding ProteinsDrosophila Proteinsmsl-2 protein, DrosophilaRibonucleoproteinsRNA-Binding ProteinsSxl protein, Drosophilatra2 protein, DrosophilaTranscription Factors

Identifiers

PMID35087103
PMCPMC8795210
OpenAlexW4220652581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.