ArticleScientific reports2022
A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The current status of FLASH particle therapy: a systematic review.Physical and engineering sciences in medicine · 2023Pooled it
- TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.Medical physics · 2026Article
- Quasi-monoenergetic deuteron acceleration via boosted coulomb explosion by reflected picosecond laser pulse.Nature communications · 2026Article
- Electron and proton FLASH beam dosimetry using unified alanine, EBT-XD, and HD-V2 Gafchromic film dosimeters.Medical physics · 2025Article
- Secondary neutron dose measurements at the DRACO laser-driven ion source.Scientific reports · 2025Article
- Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source.Scientific reports · 2025Article
- 3D protoacoustic radiography: A proof of principle study.Applied physics letters · 2025Article
- Stable laser-acceleration of high-flux proton beams with plasma collimation.Nature communications · 2025Article
- Ionic-resolution protoacoustic microscopy: A feasibility study.Applied physics letters · 2024Article
- Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023Article
- Time-of-flight spectroscopy for laser-driven proton beam monitoring.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Radiotherapy is the current standard of care for more than 50% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2 MeV energy at 0.2 Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10 mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35 Gy at ultra-high instantaneous dose rates of 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.