Observational studyScientific reports2022
EEG theta and beta bands as brain oscillations for different knee osteoarthritis phenotypes according to disease severity.
Observational study in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Brain compensatory mechanisms in depression and memory complaints in fibromyalgia: the role of theta oscillatory activity.Pain medicine (Malden, Mass.) · 2024Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Upper Limb Fatigue Information Variation Analysis Based on Parallel Brain and Muscle Functional Networks.Annals of biomedical engineering · 2026Article
- Motor cortex pain compensation is modifiable: allostatic load degrades its analgesic efficiency and rehabilitation restores it.medRxiv : the preprint server for health sciences · 2026Article
- Green light exposure reduces central sensitization in cats with osteoarthritis-associated somatosensory impairment.iScience · 2026Article
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- EEG-based clustering shows distinct separation of chronic pain patients before spinal cord stimulation surgery.NeuroImage · 2026Article
- Altered long-range temporal correlations in delta oscillatory amplitude dynamics in gambling disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Rewiring Recovery: Cognitive and Motor Gains Through Personalized Neurofeedback After Tumor Resection-A Case Series from Neurorehabilitation Practice.Applied psychophysiology and biofeedback · 2026Article
- EEG-Based Cortical Alterations in Patients Following Total Hip and Knee Arthroplasty Due to Osteoarthritis: Pre- and Post-Operative Assessment.Brain and behavior · 2026Article
- Effects of nocturnal melatonin-based tissue-bone homeostasis manipulation at varying time points on pain and central mechanisms in individuals with knee osteoarthritis: a randomized controlled trial.Frontiers in bioengineering and biotechnology · 2026Article
- Efficacy and Central Mechanism of Shexiang Zhuifeng Analgesic Plaster Combined with Transcranial Direct Current Stimulation in the Treatment of Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2026Article
- Altered activation patterns of sensorimotor cortex during level walking and stair climbing in patients with knee osteoarthritis: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- A novel application of transcranial pulse stimulation in rehabilitation: pain management in refractory knee osteoarthritis - a case series.Journal of rehabilitation medicine · 2025Article
- Enhancing classification of a large lower-limb motor imagery EEG dataset for BCI in knee pain patients.Scientific data · 2025Article
- The alternation of neural oscillations during dual task standing in older adults with low back pain.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Pain and the Brain: A Systematic Review of Methods, EEG Biomarkers, Limitations, and Future Directions.Neurology international · 2025Review
- Neurophysiological Markers of Adaptation and Compensation Following Lower Limb Amputation: An Analysis of EEG Oscillations and Clinical Predictors from the DEFINE Cohort Study.Neurology international · 2025Article
- Translational validity of quantitative sensory testing in chronic pain neuro-sensitization: guide of use and interpretation in osteoarthritis animal models.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Effects of Tissue-Bone Homeostasis Manipulation at Different Time Points on Pain and Brain Mechanisms in Patients with Knee Osteoarthritis Based on Circadian Rhythm: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
This study aims to investigate the multivariate relationship between different sociodemographic, clinical, and neurophysiological variables with resting-state, high-definition, EEG spectral power in subjects with chronic knee osteoarthritis (OA) pain. This was a cross-sectional study. Sociodemographic and clinical data were collected from 66 knee OA subjects. To identify associated factors, we performed independent univariate and multivariate regression models by frequency bands (delta, theta, alpha, beta, low-beta, and high-beta) and by pre-defined regions (frontal, central, and parietal). From adjusted multivariate models, we found that: (1) increased frontocentral high-beta power and reduced central theta activity are positively correlated with pain intensity (β = 0.012, 95% CI 0.004-0.020; and β = - 0.008; 95% CI 0.014 to - 0.003; respectively); (2) delta and alpha oscillations have a direct relationship with higher cortical inhibition; (3) diffuse increased power at low frequencies (delta and theta) are associated with poor cognition, aging, and depressive symptoms; and (4) higher alpha and beta power over sensorimotor areas seem to be a maladaptive compensatory mechanism to poor motor function and severe joint degeneration. Subjects with higher pain intensity and higher OA severity (likely subjects with maladaptive compensatory mechanisms to severe OA) have higher frontocentral beta power and lower theta activity. On the other hand, subjects with less OA severity and less pain have higher theta oscillations power. These associations showed the potential role of brain oscillations as a marker of pain intensity and clinical phenotypes in chronic knee OA patients. Besides, they suggest a potential compensatory mechanism of these two brain oscillators according to OA severity.
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Registered trials
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