ArticleScientific reports2022
Frequencies and characteristics of genome-wide recombination in Streptococcus agalactiae, Streptococcus pyogenes, and Streptococcus suis.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- The Complexity of erm-Mediated Resistance: Structural and Functional Perspectives From β-Hemolytic Streptococci.Molecular microbiology · 2026Review
- Unraveling the relationship between the vaginal microbiome and return to estrus in post-weaning sows.BMC veterinary research · 2026Article
- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- Virulence and pathogenicity of group BVirulence · 2025Review
- Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy.Nature communications · 2025Article
- PGAP2: A comprehensive toolkit for prokaryotic pan-genome analysis based on fine-grained feature networks.Nature communications · 2025Article
- Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution.Nature biotechnology · 2025Article
- Whole-Genome Sequencing Analysis Revealed High Genomic Variability, Recombination Events and Mobile Genetic Elements inAntibiotics (Basel, Switzerland) · 2025Article
- Global spread of Streptococcus pyogenes A genomics-supported narrative review.FEMS microbiology reviews · 2025Review
- Genomic analysis ofFrontiers in veterinary science · 2025Article
- Structural and genomic insights into erythromycin and clindamycin resistance of group BFrontiers in microbiology · 2025Article
- Genomic cluster formation among invasive group A streptococcal infections in the USA: a whole-genome sequencing and population-based surveillance study.The Lancet. Microbe · 2024Article
- Article
- Effects of cottonseed meal protein hydrolysate on intestinal microbiota of yellow-feather broilers.Frontiers in microbiology · 2024Article
- The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Two putative glutamate decarboxylases of Streptococcus pneumoniae as possible antigens for the production of anti-GAD65 antibodies leading to type 1 diabetes mellitus.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
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2 authors.
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Abstract
Streptococcus consists of ecologically diverse species, some of which are important pathogens of humans and animals. We sought to quantify and compare the frequencies and characteristics of within-species recombination in the pan-genomes of Streptococcus agalactiae, Streptococcus pyogenes and Streptococcus suis. We used 1081, 1813 and 1204 publicly available genome sequences of each species, respectively. Based on their core genomes, S. agalactiae had the highest relative rate of recombination to mutation (11.5743) compared to S. pyogenes (1.03) and S. suis (0.57). The proportion of the species pan-genome that have had a history of recombination was 12.85%, 24.18% and 20.50% of the pan-genomes of each species, respectively. The composition of recombining genes varied among the three species, and some of the most frequently recombining genes are implicated in adhesion, colonization, oxidative stress response and biofilm formation. For each species, a total of 22.75%, 29.28% and 18.75% of the recombining genes were associated with prophages. The cargo genes of integrative conjugative elements and integrative and mobilizable elements contained genes associated with antimicrobial resistance and virulence. Homologous recombination and mobilizable pan-genomes enable the creation of novel combinations of genes and sequence variants, and the potential for high-risk clones to emerge.
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