Evidence map›Paper›PMID 35087039›Full record

ArticleNature communications2022

Carbohydrate-aromatic interface and molecular architecture of lignocellulose.

Alex Kirui, Wancheng Zhao, Fabien Deligey, Hui Yang, Xue Kang, Frederic Mentink-Vigier, Tuo Wang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
48.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 250 citations in OpenAlex.

  1. Article
  2. Review
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  6. Reply to Cosgrove: Catalytic activity in expansin-like proteins does not explain wall creep but raises a flag.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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  14. A single-domain expansin-like protein fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Review
  17. Using Solid-State NMR to Understand the Structure of Plant Cellulose.Journal of the American Chemical Society · 2025
    Article
  18. Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alex Kirui *Department of Chemistry, Louisiana State University, Baton Rouge, LA, 70803, USA.ORCID http://orcid.org/0000-0002-9087-4283
Wancheng Zhao *Department of Chemistry, Louisiana State University, Baton Rouge, LA, 70803, USA.
Fabien Deligey *Department of Chemistry, Louisiana State University, Baton Rouge, LA, 70803, USA.
Hui YangDepartment of Biology, Pennsylvania State University, University Park, PA, 16802, USA.ORCID http://orcid.org/0000-0001-6331-6801
Xue KangDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, 70803, USA.
Frederic Mentink-VigierNational High Magnetic Field Laboratory, Tallahassee, FL, 32310, USA.ORCID http://orcid.org/0000-0002-3570-9787
Tuo WangDepartment of Chemistry, Louisiana State University, Baton Rouge, LA, 70803, USA. tuowang@lsu.edu.ORCID http://orcid.org/0000-0002-1801-924X
Louisiana State University · USNational High Magnetic Field Laboratory · USPennsylvania State University · US

Funding

TR&D3-SCHP41GM122698 · NIGMS · FLORIDA STATE UNIVERSITY · PI BREY, WILLIAM W, CROSS, TIMOTHY A · 2017 to 2021
$6.7M
14.1 T magnet with +/-1280 G Field Regulation and Integrated MAS Cryogenic SystemS10OD018519 · OD · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 2014 to 2014
$1.4M
NIGMS NIH HHS P41 GM122698NIH HHS S10 OD018519
6 · The paper itself

Abstract

Plant cell walls constitute the majority of lignocellulosic biomass and serve as a renewable resource of biomaterials and biofuel. Extensive interactions between polysaccharides and the aromatic polymer lignin make lignocellulose recalcitrant to enzymatic hydrolysis, but this polymer network remains poorly understood. Here we interrogate the nanoscale assembly of lignocellulosic components in plant stems using solid-state nuclear magnetic resonance and dynamic nuclear polarization approaches. We show that the extent of glycan-aromatic association increases sequentially across grasses, hardwoods, and softwoods. Lignin principally packs with the xylan in a non-flat conformation via non-covalent interactions and partially binds the junction of flat-ribbon xylan and cellulose surface as a secondary site. All molecules are homogeneously mixed in softwoods; this unique feature enables water retention even around the hydrophobic aromatics. These findings unveil the principles of polymer interactions underlying the heterogeneous architecture of lignocellulose, which may guide the rational design of more digestible plants and more efficient biomass-conversion pathways.

Indexed as

BiomassBiopolymersCelluloseCell WallHydrolysisLigninMagnetic Resonance SpectroscopyPlantsPoaceaePolysaccharidesXylansBiopolymersCelluloseLigninlignocellulosePolysaccharidesXylans

Identifiers

PMID35087039
PMCPMC8795156
OpenAlexW4210301269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.