Evidence map›Paper›PMID 35087026›Full record

ArticleBlood cancer journal2022

Patients in complete remission after R-CHOP(-like) therapy for diffuse large B-cell lymphoma have limited excess use of health care services in Denmark.

Lasse Hjort Jakobsen, Andreas Kiesbye Øvlisen, Marianne Tang Severinsen, Joachim Bæch, Kristian Hay Kragholm, Ingrid Glimelius, Anne Ortved Gang, Judit Mészáros Jørgensen, Henrik Frederiksen, Christian Bjørn Poulsen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Blood cancer journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 2 countries.

Lasse Hjort JakobsenDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark. lasse.j@rn.dk.ORCID 0000-0001-6575-7686
Andreas Kiesbye ØvlisenDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Marianne Tang SeverinsenDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Joachim BæchDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0001-8848-4879
Kristian Hay KragholmUnit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Aalborg, Denmark.
Ingrid GlimeliusClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-6158-3041
Anne Ortved GangDepartment of Hematology, Rigshospitalet, Copenhagen, Denmark.
Judit Mészáros JørgensenDepartment of Hematology, Aarhus University Hospital, Aarhus, Denmark.
Henrik FrederiksenDepartment of Hematology, Odense University Hospital, Odense, Denmark.ORCID 0000-0001-8905-0220
Christian Bjørn PoulsenDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark.ORCID 0000-0001-9785-1378
Michael Roost ClausenDepartment of Hematology, Vejle Sygehus, Vejle, Denmark.
Per Trøllund PedersenDepartment of Hematology, Sydvestjysk sygehus, Esbjerg, Denmark.
Robert Schou PedersenDepartment of Medicine, Holstebro sygehus, Holstebro, Denmark.
Christian Torp-PedersenDepartment of Cardiology, Nordsjællands Hospital, Hillerød, Denmark.
Sandra ElorantaClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Tarec Christoffer El-GalalyDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Aalborg University Hospital · DKAarhus University Hospital · DKHospital South West Jutland · DKKarolinska Institutet · SEOdense University Hospital · DKRegional Hospital Holstebro · DKRigshospitalet · DKUniversity of Copenhagen · DKUppsala University · SEVejle Sygehus · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For most patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), R-CHOP immunochemotherapy leads to complete remission and 60-70% of patients remain progression-free after 5 years. Given a median age of 65, it is relevant to disentangle how DLBCL and DLBCL therapy influence health care use among the survivors. In this nationwide study, the health care use among Danish DLBCL patients diagnosed in 2007-2015, who achieved complete remission after R-CHOP(-like) therapy, was explored and compared to matched comparators from the Danish general population. The post-remission 5-year risk of hospitalization was significantly higher among DLBCL survivors (55%) compared to matched comparators (49%, P < 0.001). DLBCL survivors had on average 10.3 (9.3-11.3) inpatient bed days within 5 years of response evaluation, whereas matched comparators had 8.4 (7.9-8.8). The rate of outpatient visits was also significantly higher(excluding routine follow-up visits, incidence rate ratio, 1.3, P < 0.001), but translated into only a very small absolute difference of <1 outpatient visits within 5 years between DLBCL survivors (4.2 visits, 95% CI, 4.0-4.4) and matched comparators (3.8 visits, 95% CI, 3.7-3.9). In conclusion, DLBCL survivors have an increased incidence of hospital visits due to a wide range of conditions, but in absolute terms the excess use of health care services in DLBCL survivors was small.

Indexed as

AdultAgedAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDelivery of Health CareDenmarkDoxorubicinFemaleHospitalizationHumansLymphoma, Large B-Cell, DiffuseMaleMiddle AgedOutpatientsPrednisoneRemission InductionCyclophosphamideDoxorubicinPrednisoneR-CHOP protocolRituximabVincristine

Identifiers

PMID35087026
PMCPMC8795387
OpenAlexW4210443224

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.