Evidence map›Paper›PMID 35086892›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Assessing Reactive Astrogliosis with

Victor L Villemagne, Ryuichi Harada, Vincent Doré, Shozo Furumoto, Rachel Mulligan, Yukitsuka Kudo, Samantha Burnham, Natasha Krishnadas, Pierrick Bourgeat, Ying Xia and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Feasibility of short imaging protocols for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Astrocyte reactivity across the AD continuum measured by [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Review
  7. Review
  8. Early astrocyte-targeted intervention guided byEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. IND-Enabling Preclinical Studies of [Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2025
    Article
  13. Kinetic and quantitative analysis of [Annals of nuclear medicine · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Automated radiosynthesis and clinical experience of [Frontiers in nuclear medicine · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Victor L VillemagneDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia; victor.villemagne@pitt.edu.
Ryuichi HaradaDepartment of Pharmacology, School of Medicine, Tohoku University, Sendai, Japan.
Vincent DoréDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Shozo FurumotoCyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Rachel MulliganDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Yukitsuka KudoInstitute of Development of Aging and Cancer, Tohoku University, Sendai, Japan.
Samantha BurnhamCSIRO Health and Biosecurity Flagship: Australian e-Health Research Centre, Melbourne, Victoria, Australia.
Natasha KrishnadasDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Pierrick BourgeatCSIRO: Australian e-Health Research Centre, Brisbane, Queensland, Australia.
Ying XiaCSIRO: Australian e-Health Research Centre, Brisbane, Queensland, Australia.
Simon LawsSchool of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Svetlana BozinovskiDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Kun HuangDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Milos D IkonomovicDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jürgen FrippCSIRO: Australian e-Health Research Centre, Brisbane, Queensland, Australia.
Kazuhiko YanaiDepartment of Pharmacology, School of Medicine, Tohoku University, Sendai, Japan.
Nobuyuki OkamuraDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.
Austin Health · AUTohoku University · JPUniversity of Pittsburgh · USBreast Cancer Network Australia · AUEdith Cowan University · AUJapan Radioisotope Association · JPTohoku Medical and Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A neuroinflammatory reaction in Alzheimer disease (AD) brains involves reactive astrocytes that overexpress monoamine oxidase-B (MAO-B).

Indexed as

Alzheimer DiseaseQuinolinesAmyloid beta-PeptidesAustraliaBiomarkersCross-Sectional StudiesFemaleGliosisHumansInflammationMaleMonoamine OxidaseAmyloid beta-PeptidesBiomarkersMonoamine OxidaseQuinolinesAlzheimer diseaseamyloidbrain imagingMAO-Breactive astrogliosistau

Identifiers

PMID35086892
PMCPMC9536709
OpenAlexW4210783483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.