Evidence map›Paper›PMID 35086840›Full record

ArticleThe European respiratory journal2022

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.

Konstantinos Evangelou, Dimitris Veroutis, Koralia Paschalaki, Periklis G Foukas, Nefeli Lagopati, Marios Dimitriou, Angelos Papaspyropoulos, Bindu Konda, Orsalia Hazapis, Aikaterini Polyzou and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. Article
  7. Review
  8. Cellular sensor DAP5 decodesFrontiers in immunology · 2026
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  17. Senotherapy for chronic lung disease.Pharmacological reviews · 2025
    Review
  18. Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 5 countries.

Konstantinos EvangelouMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitris VeroutisMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Koralia PaschalakiNational Heart and Lung Institute, Imperial College London, London, UK.
Periklis G Foukas2nd Dept of Pathology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Nefeli LagopatiMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Marios Dimitriou2nd Dept of Pathology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0001-5699-2289
Angelos PapaspyropoulosMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Bindu KondaLung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Orsalia HazapisMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Aikaterini PolyzouMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Sophia HavakiMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Athanassios KotsinasMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Christos KittasMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Athanasios G TzioufasDept of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Laurence de LevalInstitute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
Demetris VassilakosMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Sotirios Tsiodras4th Dept of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.
Barry R StrippLung and Regenerative Medicine Institutes, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Argyris PapantonisTranslational Epigenetics Group, Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Giovanni BlandinoOncogenomic and Epigenetic Unit, IRCCS, Regina Elena National Cancer Institute, Rome, Italy.
Ioannis KarakasiliotisLaboratory of Biology, Dept of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Peter J BarnesNational Heart and Lung Institute, Imperial College London, London, UK.
Vassilis G GorgoulisMolecular Carcinogenesis Group, Dept of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece vgorg@med.uoa.gr.
National and Kapodistrian University of Athens · GRCedars-Sinai Medical Center · USDemocritus University of Thrace · GRBarnes Hospital · GBImperial College London · GBUniversity of Cologne · DEUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the respiratory system can progress to a multisystemic disease with aberrant inflammatory response. Cellular senescence promotes chronic inflammation, named senescence-associated secretory phenotype (SASP). We investigated whether coronavirus disease 2019 (COVID-19) is associated with cellular senescence and SASP.

methodsAutopsy lung tissue samples from 11 COVID-19 patients and 43 age-matched non-COVID-19 controls with similar comorbidities were analysed by immunohistochemistry for SARS-CoV-2, markers of senescence and key SASP cytokines. Virally induced senescence was functionally recapitulated

resultsSARS-CoV-2 was detected by immunocytochemistry and electron microscopy predominantly in AT2 cells. Infected AT2 cells expressed angiotensin-converting enzyme 2 and exhibited increased senescence (p16

conclusionsWe demonstrate that in severe COVID-19, AT2 cells infected by SARS-CoV-2 exhibit senescence and a proinflammatory phenotype.

Indexed as

COVID-19SARS-CoV-2Cellular SenescenceCytokinesHumansInflammationInterleukin-6LungMutagenesisPhenotypeCytokinesInterleukin-6

Identifiers

PMID35086840
PMCPMC8796696
OpenAlexW4210558603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.