ArticleThe international journal of behavioral nutrition and physical activity2022
Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain.
Article in The international journal of behavioral nutrition and physical activity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies.Diabetes care · 2023Pooled it
- Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes.Cardiovascular diabetology · 2023Trial
- Healthy lifestyle and related metabolomic signatures associated with decreased risk and delayed progression of type 2 diabetes mellitus transitions: a large prospective cohort study.Acta diabetologica · 2026Article
- Healthy lifestyle, metabolomic signature, and risk of late-onset schizophrenia: evidence from the prospective cohort.Schizophrenia (Heidelberg, Germany) · 2026Article
- Advanced Bayesian kernel machine regression for large-scale exposome studies: Making the impossible possible.Innovation (Cambridge (Mass.)) · 2026Article
- Association of Unhealthy Lifestyles with Cataract Risk, and The Mediating Role of Metabolic Signature: Analysis of the UK Biobank Prospective Cohort.Aging and disease · 2025Article
- Prospective association of a Lifestyle Risk Factor Index with type 2 diabetes in the Multiethnic Cohort.European journal of nutrition · 2025Article
- The association between metabolomic profiles of lifestyle and the latent phase of incident chronic kidney disease in the UK Population.Scientific reports · 2025Article
- Combining Ability ofCurrent issues in molecular biology · 2024Article
- Healthy Lifestyle, Metabolic Signature, and Risk of Cardiovascular Diseases: A Population-Based Study.Nutrients · 2024Article
- Association between healthy lifestyle and frailty in adults and mediating role of weight-adjusted waist index: results from NHANES.BMC geriatrics · 2024Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.Scientific reports · 2024Article
- Metabolomic Profile Alterations Associated with theCurrent developments in nutrition · 2024Article
- Metabolomics and Lipidomics for Studying Metabolic Syndrome: Insights into Cardiovascular Diseases, Type 1 & 2 Diabetes, and Metabolic Dysfunction-Associated Steatotic Liver Disease.Physiological research · 2024Review
- Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.Med (New York, N.Y.) · 2024Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.medRxiv : the preprint server for health sciences · 2023Article
- Metabolite Signature of Life's Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans.Circulation. Genomic and precision medicine · 2023Article
- Nano-Stevia reduces the liver injury caused by streptozotocin (STZ)-induced diabetes in rats by targeting PEPCK/GCK genes, INSR pathway and apoptosis.Journal of diabetes and metabolic disorders · 2023Article
- Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid.Nutrition & metabolism · 2023Article
- Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease.Cardiovascular diabetology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes.
methodsA Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001-2003, and were followed-up to 2015 to ascertain incident type 2 diabetes.
resultsThe HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and - 8.23 (95% CI, - 16.34, - 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes.
conclusionsThe HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis.
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