Evidence map›Paper›PMID 35086538›Full record

ReviewImplementation science : IS2022

Implementability of healthcare interventions: an overview of reviews and development of a conceptual framework.

Marlena Klaic, Suzanne Kapp, Peter Hudson, Wendy Chapman, Linda Denehy, David Story, Jill J Francis

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Implementation science : IS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 205 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06987708 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study

TypeinterventionalSponsorHackensack Meridian HealthRan2026 to 2028Enrolled67ConditionsMonoclonal Gammopathy of Uncertain Significance, Smoldering MyelomaArmsThe Multimodal Lifestyle Intervention
NCT07420881 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Start 4 All - DARE-TB

TypeinterventionalSponsorLiverpool School of Tropical MedicineRan2026 to 2027Enrolled60,000ConditionsTB - TuberculosisArmsNear point of care (NPOC) NAATs, Low-complexity nucleic acid amplification tests (LC-NAATs), LC-NAAT using pooled testing, Computer-Aided Detection (CAD) Chest X-ray (CXR-AI), Culture (reference standard)
NCT07517471 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Start4All - Start Taking Action for TB Diagnosis SCREEN-TB

TypeinterventionalSponsorLiverpool School of Tropical MedicineRan2026 to 2027Enrolled37,000ConditionsTB - TuberculosisArmsNear point of care (NPOC) NAATs, Low-complexity nucleic acid amplification tests (LC-NAATs), LC-NAAT using pooled testing, Portable Chest X-ray Image Acquisition, Computer-Aided Detection (CAD) Chest X-ray (CXR-AI)
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  8. Understanding factors impacting patient-reported outcome measures integration in routine clinical practice: an umbrella review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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  9. Effects of Prenatal Breastfeeding Education on Breastfeeding Duration Beyond 12 Weeks: A Systematic Review.Health education & behavior : the official publication of the Society for Public Health Education · 2024
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  11. Operationalizing the Consolidated Framework for Implementation Research to build and support the lived experience workforce in direct health service provision.Health expectations : an international journal of public participation in health care and health policy · 2024
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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marlena KlaicThe University of Melbourne, School of Health Sciences, Melbourne, Australia. marlena.klaic@unimelb.edu.au.ORCID 0000-0003-2328-0503
Suzanne KappThe University of Melbourne, School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, Department of Nursing, Melbourne, Australia.ORCID 0000-0002-5438-8384
Peter HudsonThe University of Melbourne, School of Health Sciences, Melbourne, Australia.ORCID 0000-0001-5891-8197
Wendy ChapmanCentre for Digital Transformation of Health, The University of Melbourne, Melbourne, Australia.ORCID 0000-0001-8702-4483
Linda DenehyThe University of Melbourne, School of Health Sciences, Melbourne, Australia.ORCID 0000-0002-2926-8436
David StoryDepartment of Critical Care, The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-6479-1310
Jill J FrancisThe University of Melbourne, School of Health Sciences, Melbourne, Australia.ORCID 0000-0001-5784-8895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImplementation research may play an important role in reducing research waste by identifying strategies that support translation of evidence into practice. Implementation of healthcare interventions is influenced by multiple factors including the organisational context, implementation strategies and features of the intervention as perceived by people delivering and receiving the intervention. Recently, concepts relating to perceived features of interventions have been gaining traction in published literature, namely, acceptability, fidelity, feasibility, scalability and sustainability. These concepts may influence uptake of healthcare interventions, yet there seems to be little consensus about their nature and impact. The aim of this paper is to develop a testable conceptual framework of implementability of healthcare interventions that includes these five concepts.

methodsA multifaceted approach was used to develop and refine a conceptual framework of implementability of healthcare interventions. An overview of reviews identified reviews published between January 2000 and March 2021 that focused on at least one of the five concepts in relation to a healthcare intervention. These findings informed the development of a preliminary framework of implementability of healthcare interventions which was presented to a panel of experts. A nominal group process was used to critique, refine and agree on a final framework.

resultsA total of 252 publications were included in the overview of reviews. Of these, 32% were found to be feasible, 4% reported sustainable changes in practice and 9% were scaled up to other populations and/or settings. The expert panel proposed that scalability and sustainability of a healthcare intervention are dependent on its acceptability, fidelity and feasibility. Furthermore, acceptability, fidelity and feasibility require re-evaluation over time and as the intervention is developed and then implemented in different settings or with different populations. The final agreed framework of implementability provides the basis for a chronological, iterative approach to planning for wide-scale, long-term implementation of healthcare interventions.

conclusionsWe recommend that researchers consider the factors acceptability, fidelity and feasibility (proposed to influence sustainability and scalability) during the preliminary phases of intervention development, evaluation and implementation, and iteratively check these factors in different settings and over time.

Indexed as

Delivery of Health CareHealth FacilitiesHumansPublicationsResearch PersonnelFrameworkHealthcare interventionsImplementabilityImplementation researchImplementation scienceImplementation strategiesScalabilitySustainability

Identifiers

PMID35086538
PMCPMC8793098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.