ArticleBMC musculoskeletal disorders2022
Muscle weakness is associated with non-contractile muscle tissue of the vastus medialis muscle in knee osteoarthritis.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Assessment of vastus medialis muscle quality in knee osteoarthritis using ultrashort echo time magnetization transfer MR imaging.Skeletal radiology · 2025Article
- Quantifying structural properties of forearm flexor muscles in individuals with hemiparetic cerebral palsy using diffusion tensor imaging.Physiological reports · 2025Article
- Methodology Development for Investigating Pathophysiological [Biomedicines · 2025Article
- Application of multidimensional gait feature fusion algorithm in gait assessment for patients with knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2025Article
- Assessment of Quadriceps Muscle in Advanced Knee Osteoarthritis and Correlation with Lower Limb Alignment.Medicina (Kaunas, Lithuania) · 2024Article
- [Postoperative rehabilitation after knee arthroplasty].Orthopadie (Heidelberg, Germany) · 2024Review
- A causative role for periarticular skeletal muscle weakness in the progression of joint damage and pain in OA.Scientific reports · 2023Article
- Article
- Relationship Between Preoperative Psoas Major Muscle Quality and Forgotten Joint Score-12 in Patients After Total Hip Arthroplasty.Arthroplasty today · 2023Article
- Change of the cross-sectional area of vastus medialis oblique in patients with recurrent patellar dislocation treated by tibial tubercle transfer combined with medial patellofemoral ligament reconstruction on axial CT.Journal of orthopaedic surgery and research · 2022Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuadriceps weakness is assumed to be associated with compositional properties of the vastus medialis muscle in patients with knee osteoarthritis (OA).
methodsThe aim was to determine the association of non-contractile muscle tissue in the vastus medialis muscle, measured with routine MRI, with muscle extensor strength in patients with knee OA. Sagittal T1-weighted 3T MRI of 94 patients with knee OA, routinely acquired in clinical practice were used for analysis. Using the MRI's, the amount of non-contractile muscle tissue in the vastus medialis muscle was measured, expressed as a percentage of (non)-contractile tissue, dichotomized into a low and a high non-contractile percentage group. Muscle strength was assessed by isokinetic measurement of knee extensors and by conduction of the Get-Up and Go (GUG) test. In regression analyses, associations of percentage of non-contractile muscle tissue with muscle strength and GUG time were determined and controlled for sex, age, BMI and radiographic severity.
resultsA high percentage of non-contractile muscle tissue (> 11.2%) was associated with lower muscle strength (B = -0.25, P = 0.006) and with longer GUG time (B = 1.09, P = 0.021). These associations were specifically confounded by sex and BMI, because these two variables decreased the regression coefficient (B) with > 10%.
conclusionsA high percentage of non-contractile muscle tissue in the vastus medialis muscle measured by clinical T1-weighted 3T MRI is associated with muscle weakness. The association is confounded by sex and BMI. Non-contractile muscle tissue seems to be an important compositional property of the vastus medialis muscle underlying quadriceps weakness.
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