Evidence map›Paper›PMID 35086494›Full record

ArticleBMC nephrology2022

Association of abnormal electrocardiograph metrics with prolonged recovery time in incident hemodialysis patients.

Jacqueline Watt, Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Michelle M Estrella, Larisa G Tereshchenko, Jose M Monroy-Trujillo, Michael Walsh, Rulan S Parekh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Jacqueline WattChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Jessica FitzpatrickChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada.
Stephen M SozioDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bernard G JaarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michelle M EstrellaKidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, USA.
Larisa G TereshchenkoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jose M Monroy-TrujilloDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael WalshDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Rulan S ParekhChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada. rulan.parekh@sickkids.ca.
Johns Hopkins University · USHospital for Sick Children · CAInstitute for Clinical Evaluative Sciences · CAMcMaster University · CANephrology Center of Maryland · USOregon Health & Science University · USUniversity of California, San Francisco · US

Funding

Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
Novel ECG measures and risk of sudden cardiac deathR56HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2018 to 2018
$396k
6 · The paper itself

Abstract

backgroundPatients receiving intermittent hemodialysis have variable times of recovery to feeling better after dialysis. QT prolongation, a precursor to clinical and subclinical cardiovascular events, may contribute to delayed recovery time. We hypothesized that abnormal electrocardiographic parameters indicating perturbations in ventricular action are associated with longer recovery times thus impacting a patient-centered quality of life.

methodsAmong 242 incident in-center hemodialysis participants from the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study, corrected QT interval (QTc), QRST angle and heart rate variance were measured on non-dialysis days using a standard 5-min electrocardiograph recording. Left ventricular hypertrophy (LVH) was defined using the Cornell voltage product. Recovery time was ascertained during a phone interview with a standardized validated questionnaire. Associations between QTc, QRST angle, heart rate variance, and LVH and natural log-transformed recovery time were examined using linear regression adjusted for participant characteristics and electrolytes.

resultsMean age was 55 (standard deviation 13) years, 55% were male, 72% were African American. Longer QTc interval was associated with increased recovery time (per 10 ms increase in QTc, recovery time increased by 6.2%; 95% confidence interval: 0.0-10.5). QRST angle, heart rate, heart rate variability and LVH were not significantly associated with recovery time.

conclusionLonger QTc intervals are associated with longer recovery time independent of serum electrolytes. This supports a relationship between a patient's underlying arrhythmic status and time to recovery after hemodialysis. Future studies will determine if maneuvers to reduce QTc improves recovery time and quality of life of patients on hemodialysis.

Indexed as

ElectrocardiographyRenal DialysisAdultAgedFemaleHeart VentriclesHumansKidney Failure, ChronicMaleMiddle AgedProspective StudiesQuality of LifeTime FactorsArrhythmiasDialysisElectrocardiographyESRDHemodialysisIncidentQTcQT intervalRecovery timeSudden cardiac death

Identifiers

PMID35086494
PMCPMC8796483
OpenAlexW4210500224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.