Evidence map›Paper›PMID 35086423›Full record

ArticleRenal failure2022

Combined serum free light chain predicts prognosis in acute kidney injury following cardiovascular surgery.

Wenji Wang, Lulu Zhang, Tianye Yang, Shaojun Ma, Qi Zhang, Peng Shi, Feng Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenji WangSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Lulu ZhangSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Tianye YangSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Shaojun MaSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Qi ZhangSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.
Peng ShiDepartment of Medical Statistics, Children's Hospital; Center for Evidence-based Medicine, Fudan University, Shanghai, PR China.
Feng DingSchool of Medicine, Division of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIncreased polyclonal free light chains (FLCs) are found in inflammatory conditions. Inflammation is recognized in the progression of acute kidney injury (AKI). This study was aimed to determine whether polyclonal combined FLC (cFLC) was associated with prognosis of AKI patients.

methodsThis prospective cohort included 145 adults with hospital-acquired AKI following cardiovascular surgery between 2014 and 2016, according to the KDIGO creatinine criteria. The primary end point of the study was all-cause death during follow-up.

resultsThe median of serum cFLC concentration in the cohort was 42.0 (31.9-60.3 mg/L) and levels of cFLC in patients with AKI stage 3 were higher than those in AKI stage 1 and stage 2. cFLC levels correlated significantly with renal function biomarkers, high sensitivity C-reactive protein (hsCRP), and sequential organ failure assessment (SOFA) score. Patients were organized into the following two groups: the low-cFLC group (cFLC <43.3 mg/L) and the high-cFLC group (cFLC ≥ 43.3 mg/L). A total of 17 (11.0%) patient deaths occurred within 90 d, 13 (18.8%) in the high-cFLC group. Kaplan-Meier analysis revealed that the two groups differed significantly with respect to 90-d survival (log-rank

conclusionsSerum cFLC levels were significantly elevated and might be an independent predictor of mortality in patients with AKI following cardiovascular surgery.

Indexed as

Acute Kidney InjuryAdultAgedBiomarkersCardiovascular Surgical ProceduresCause of DeathC-Reactive ProteinCreatinineFemaleHumansImmunoglobulin Light ChainsMaleMiddle AgedPostoperative ComplicationsPrognosisProspective StudiesBiomarkersC-Reactive ProteinCreatinineImmunoglobulin Light ChainsAcute kidney injuryall-cause mortalityfree light chainprognosis

Identifiers

PMID35086423
PMCPMC8797736

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