Evidence map›Paper›PMID 35086399›Full record

ArticlePharmaceutical biology2021

Study on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria.

Jiqing Bai, Xiaoping Wang, Shaobing Du, Pengfei Wang, Yaheng Wang, Lina Quan, Yundong Xie

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Components ofFrontiers in pharmacology · 2026
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  10. MethanolicFrontiers in pharmacology · 2022
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiqing BaiCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Xiaoping WangCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Shaobing DuCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Pengfei WangCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Yaheng WangCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Lina QuanCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Yundong XieCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
Shaanxi University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextDanshen, the dried root and rhizome of

objectiveTo study the effects of DHHP on MIRI and mechanisms based on apoptosis and mitochondria. MATERIALS AND

methods36 SD rats (

resultsMyocardial infarct sizes were, respectively, 0.35%, 40.09%, 15.84%, 30.13%, concentrations of NAD

conclusionsThe improvement of MIRI by DHHP may be involved in inhibiting MPTP opening, decreasing oxidative damage, alleviating ischaemic injury and inhibiting cardiomyocyte apoptosis.

Indexed as

AnimalsApoptosisCarthamus tinctoriusCell LineDose-Response Relationship, DrugDrugs, Chinese HerbalMaleMitochondriaMitochondrial Permeability Transition PoreMyocardial InfarctionMyocardial Reperfusion InjuryMyocytes, CardiacRandom AllocationRatsRats, Sprague-DawleySalvia miltiorrhizadan-shen root extractDrugs, Chinese HerbalHonghua extract, Carthamus tinctoriusMitochondrial Permeability Transition Porecardiomyocyte apoptosisExtracts of Chinese medicinemyocardial injurymyocardial mitochondria

Identifiers

PMID35086399
PMCPMC8797739
OpenAlexW4210553890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.