ArticleIndian journal of ophthalmology2022
Sensitivity and specificity of potassium hydroxide and calcofluor white stain to differentiate between fungal and
Article in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- The 2023 Doyne Lecture-a cornea care system: evolution.Eye (London, England) · 2024Article
- Efficacy and Rapidity of Potassium Hydroxide Mount and Modified Chicago Sky Blue 6B Stain with Potassium Hydroxide in Fungal Keratitis Detection.Korean journal of ophthalmology : KJO · 2024Article
- Understanding barriers, recommended solutions, and future prospects for the diagnosis and management of Pythium insidiosum keratitis.Indian journal of ophthalmology · 2023Article
- The Case for Fungal Keratitis to Be Accepted as a Neglected Tropical Disease.Journal of fungi (Basel, Switzerland) · 2022Review
- Clinical differentiation ofIndian journal of ophthalmology · 2022Article
- Pythium insidiosum Keratitis: Past, Present, and Future.Ophthalmology and therapy · 2022Review
- Nested PCR Detection ofVeterinary sciences · 2022Article
- Comment on: Sensitivity and specificity of potassium hydroxide and calcofluor white stain to differentiate between fungal andIndian journal of ophthalmology · 2022Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the sensitivity of potassium hydroxide and calcofluor white (KOH+CFW) mount in the diagnosis of Pythium keratitis and concordance among microbiologists.
methodsThree microbiologists evaluated the microscopic images of KOH + CFW mounts of confirmed cases of Pythium and fungal keratitis seen between January 2019 and February 2021. The filaments were compared using specific differentiating features. The sensitivity and specificity of KOH + CFW in diagnosing Pythium infection were evaluated along with concordance among the microbiologists.
resultsSixty consecutive cases with confirmed growth of fungus or Pythium insidiosum (n = 29) were evaluated. The sensitivity of KOH + CFW in the correct identification of Pythium filaments ranged from 79.3% to 96.5% among three microbiologists. There was good interobserver (k = 0.76-0.90) and intraobserver (k = 0.70-0.97) agreements among three microbiologists. The differentiating findings (P < 0.0001) suggestive of Pythium filaments were the absence of septae in 23 (79.3%) and collapsed walls in 22 (75.9%) cases.
conclusionKOH + CFW has good sensitivity and specificity in the diagnosis of Pythium keratitis with good interobserver and intraobserver concordance.
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