ArticleIndian journal of ophthalmology2022
Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty.
Article in Indian journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- A study of the utilization profile of donor corneas with a death-to-retrieval time of more than twelve hours.Indian journal of ophthalmology · 2026Article
- Medical and economic impacts of managing corneas from older donors at the tissue bank-a single-center retrospective study spanning over 12 years.Frontiers in medicine · 2024Article
- Commentary: Utilization rate of corneal tissue obtained from donors over 75 years of age in Western India for keratoplasty.Indian journal of ophthalmology · 2022Article
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the utilization patterns of cornea procured from diseased individuals ≥75 years of age at an eye bank in western India.
methodsIn this retrospective study, data from 1,217 eyes of 653 donors with age ≥75 years were reviewed from October 2008 to December 2019. Donor age, lens status, endothelial cell count (ECD), utilization of the tissue for transplantation or non-clinical purposes (e.g., research, training/discarded), and causes of non-utilization were noted.
resultsThe mean age of the donors was 80.9 ± 4.6 years and the tissue utilization rate was 36.5% (445 out of 1,217 eyes). The eyes used for keratoplasty procedures had a lower donor age (79.6 ± 5.7 vs. 81.5 ± 5.1; P < 0.001), a higher endothelial cell count (2493 ± 531 vs. 2034 ± 581; P < 0.001), and were more often phakic (61% vs. 36.6%) compared to the unused group. A multivariable logistic regression analysis showed that the likelihood of tissue utilization for keratoplasty was 13% higher with every 100-cell increment in donor ECD (odds ratio [OR] = 1.13, 95% CI = 1.10-1.16, P < 0.001) and 33% lower with having a pseudophakic status in the donor eye (OR = 0.67, 95% CI = 0.52-0.87, P = 0.03). Age was not a significant determinant of tissue utilization when used in the same multivariable model.
conclusionMore than one-third of the eyes (36.5%) can be utilized even when the donors are above 75 years of age. Eyes that were more likely to be utilized for keratoplasty were phakic and had a significantly higher ECD; age was not a determinant in tissue utilization.
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