Evidence map›Paper›PMID 35086107›Full record

ArticleActa haematologica2022

Distinct Mechanisms of IgM Antibody-Mediated Acquired von Willebrand Syndrome and Successful Treatment with Recombinant von Willebrand Factor in One Patient.

Matthias Höpting, Ulrich Budde, Andreas Tiede, Matthias Grube, Joachim Hahn, Wolfgang Herr, Susanne Heimerl, Christina Hart

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthias HöptingDepartment of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Ulrich BuddeMedilys Laborgesellschaft mbH, Asklepios Klinik Hamburg-Altona, Hamburg, Germany.
Andreas TiedeDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Matthias GrubeDepartment of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Joachim HahnDepartment of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Wolfgang HerrDepartment of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Susanne HeimerlInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Christina HartDepartment of Hematology and Oncology, Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
University Hospital Regensburg · DEAsklepios Klinik Altona · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired von Willebrand Syndrome (AVWS) is a rare coagulation disorder which can be associated with IgM paraproteinaemia. Recently, recombinant von Willebrand factor (rVWF) has become available for the treatment of bleedings in patients with inherited von Willebrand disease, but experience in patients with AVWS is limited. We report on 2 patients with AVWS with underlying IgM paraproteinaemia with distinct underlying pathomechanisms. In 1 patient, the paraprotein built unspecific complexes with von Willebrand factor (VWF). In the other patient, we were able to detect an IgM antibody against VWF. Bleeding in this patient was successfully treated with rVWF. To our knowledge, this is the first report about the successful use of rVWF in a patient with AVWS with the detection of a VWF-specific antibody.

Indexed as

Paraproteinemiasvon Willebrand DiseasesHemorrhageHumansImmunoglobulin Mvon Willebrand FactorImmunoglobulin Mvon Willebrand FactorAcquired von Willebrand syndromeBleeding disordersMonoclonal gammopathy of undetermined significanceParaproteinaemiavon Willebrand factor

Identifiers

PMID35086107
PMCPMC9501758
OpenAlexW4210801891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.