ArticleBiosensors & bioelectronics2022
Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterials.
Article in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 55 citations in OpenAlex.
- Research Progress of Terahertz Technology in Microbiology.Biosensors · 2026Review
- Nanogap-enhanced terahertz suppression of superconductivity.Nanophotonics (Berlin, Germany) · 2025Article
- Terahertz integrated sensing and mobile communications empowered by a 220-GHz-band portable device.Nature communications · 2025Article
- Transfer Learning Empowered Multiple-Indicator Optimization Design for Terahertz Quasi-Bound State in the Continuum Biosensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fabrication and application of 3D Terahertz metamaterials with vertical multinanogaps for spectroscopic sensing.Scientific reports · 2025Article
- Recent Advances in Metasurfaces: From THz Biosensing to Microwave Wireless Communications.Research (Washington, D.C.) · 2025Review
- CRISPR/Cas12a cleavage triggered nanoflower for fluorescence-free and target amplification-free biosensing of ctDNA in the terahertz frequencies.Biomedical optics express · 2024Article
- Review
- Application of Biosensors in Detecting Breast Cancer Metastasis.Sensors (Basel, Switzerland) · 2023Review
- Terahertz virus-sized gold nanogap sensor.Nanophotonics (Berlin, Germany) · 2023Article
- Terahertz Enhanced Sensing of Uric Acid Based on Metallic Slot Array Metamaterial.Micromachines · 2022Article
- Editorial on COVID-19 biosensing technologies- 2d Edition.Biosensors & bioelectronics · 2022Article
- Metasurfaces for Sensing Applications: Gas, Bio and Chemical.Sensors (Basel, Switzerland) · 2022Review
- Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike protein.Talanta · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of effective assay techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently received research attention due to its rapid worldwide spread and considerable risk to human health. The receptor-binding domain (RBD) of the spike (S) protein in SARS-CoV-2, a key component for viral entry that has a unique sequence compared to other structural proteins, has been considered an important diagnostic target. In this respect, low-frequency vibrational modes have the advantage of providing information about compositional and structural dependencies at the peptide level. In this study, the sensitive and selective detection of peptides derived from the RBD in SARS-CoV-2 and SARS-CoV was investigated using metamaterial-based sensing chips with a terahertz time-domain spectroscopy (THz-TDS) system. Based on their RBD sequences, two pairs of peptides with 20 residues each were prepared. The sensitivity, specificity, and reproducibility of the proposed system were examined via quantitative analysis using THz metamaterials at three resonance frequencies, and it was found that the species could be discriminated based on their sequences. The THz signals were analyzed with regard to the major amino acid components of the peptides, and the molecular distributions were also investigated based on the hydropathy and net charge of the peptides.
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