Evidence map›Paper›PMID 35085573›Full record

ReviewExperimental neurology2022

Transneuronal tracing to map connectivity in injured and transplanted spinal networks.

Tara A Fortino, Margo L Randelman, Adam A Hall, Jasbir Singh, David C Bloom, Esteban Engel, Daniel J Hoh, Shaoping Hou, Lyandysha V Zholudeva, Michael A Lane

Abstract readReview
In one paragraph

Review in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tara A FortinoDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America.
Margo L RandelmanDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America.
Adam A HallDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America.
Jasbir SinghDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32608, United States of America.
David C BloomDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, FL 32608, United States of America.
Esteban EngelNeuroscience Institute & Viral Core, Princeton University, Princeton, NJ, 08544, United States of America.
Daniel J HohDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, 32608, United States of America.
Shaoping HouDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America.
Lyandysha V ZholudevaGladstone Institutes, San Francisco, CA, United States of America.
Michael A LaneDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America; The Marion Murray Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA 19129, United States of America. Electronic address: mlane.neuro@gmail.com.

Funding

Spinal dopaminergic mechanisms regulating the micturition reflex after spinal cord injuryR01NS099076 · NINDS · DREXEL UNIVERSITY · PI HOU, SHAOPING · 2017 to 2021
$1.8M
Neural transplants to promote respiratory plasticity after spinal cord injuryR01NS104291 · NINDS · DREXEL UNIVERSITY · PI LANE, MICHAEL ARON · 2018 to 2022
$1.7M
Engineering Human Interneurons for Neural RepairF32NS119348 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI ZHOLUDEVA, LYANDYSHA VIKTOROVNA · 2021 to 2022
$91k
Tailoring Neural Transplants for Cervical Spinal Cord RepairF31NS125975 · NINDS · DREXEL UNIVERSITY · PI FORTINO, TARA · 2022 to 2022
$47k
NINDS NIH HHS F31 NS125975NINDS NIH HHS F32 NS119348NINDS NIH HHS R01 NS099076NINDS NIH HHS R01 NS104291
6 · The paper itself

Abstract

It has become widely appreciated that the spinal cord has significant neuroplastic potential, is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that we once understood now comprise a new anatomy. Harnessing advances in neuroanatomical tracing to map the neuronal networks of the intact and injured spinal cord has been crucial to elucidating this new spinal cord anatomy. Many new techniques have been developed to identify these networks using a variety of retrograde and anterograde tracers. One method of tracing that has become more widely used to map anatomical changes is transneuronal tracing. Viral tracers are being increasingly used to map spinal networks, leading to an advanced understanding of spinal circuitry and host-donor-host interactions between the injured spinal cord and neural transplants. This review will highlight advances in neuronal tracing, specifically using pseudorabies virus (PRV), and its use in the intact, injured, and transplanted spinal cord.

Indexed as

Herpesvirus 1, SuidSpinal Cord InjuriesAnimalsNeuronal PlasticityNeuronsSpinal CordNeural networksSpinal cord injurySpinal interneuronsTransneuronal tracingTransplantation

Identifiers

PMID35085573
PMCPMC9361710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.