ArticleDevelopmental cell2022
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression.
Open access · greenAbstract read
In one paragraph
Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
100 citing papers in PubMed, 137 citations in OpenAlex.
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- Labeling, isolation and characterization of cell-type-specific exosomes derived from mouse skin tissue.Nature protocols · 2026Review
- How Effective are Exosomes in Overcoming Blood-Labyrinth Barrier in Sensorineural Hearing Loss? A Comprehensive Review of the Literature.International journal of nanomedicine · 2026Review
- Extracellular vesicles as emerging platforms for modulating innate immune responses in sepsis-associated acute lung injury.Frontiers in immunology · 2026Review
- Exosome-Mediated Regulation of Aerobic Glycolysis in Hepatocellular Carcinoma: Mechanisms and Therapeutic Implications.Journal of hepatocellular carcinoma · 2026Review
- Research progress on the roles of extracellular vesicles in tumor immunity and drug resistance.Frontiers in immunology · 2026Review
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40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 3 institutions in 1 country.
Wei ZhangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenqun ZhongDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Beike WangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jiegang YangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jingbo YangDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ziyan YuDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhiyuan QinDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alex ShiDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei XuAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cathy ZhengAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lynn M SchuchterAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Giorgos C KarakousisDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tara C MitchellAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ravi AmaravadiAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Meenhard HerlynMolecular and Cellular Oncogenesis Program and Melanoma Research Center, The Wistar Institute, Philadelphia, PA 19104, USA.
Haidong DongDepartments of Urology and Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Phyllis A GimottyAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA 19104, USA.
George DaaboulNanoView Biosciences, Inc., Boston, MA 02135, USA.
Xiaowei XuAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wei GuoDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: guowei@sas.upenn.edu.
University of Pennsylvania · USMayo Clinic · USThe Wistar Institute · US
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MTargeting exosomal PDL1 to improve immunotherapyP50CA261608 · NCI · WISTAR INSTITUTE · PI VILLANUEVA, JESSIE · 2021 to 2025
$11.3MTargeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1MA physical sciences approach to investigate the role of exosomes in metastatic progressionU01CA250044 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GUO, WEI, RADHAKRISHNAN, RAVI · 2021 to 2025
$3.9MMolecular Basis and Regulatory Mechanisms of Exosome SecretionR35GM141832 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WEI GUO · 2021 to 2026
$3.9MTargeting dual functions of PD-L1 for cancer therapyR01CA256927 · NCI · MAYO CLINIC ROCHESTER · PI DONG, HAIDONG · 2021 to 2025
$1.8MNCI NIH HHS P30 CA010815NCI NIH HHS P50 CA174523NCI NIH HHS P50 CA261608NCI NIH HHS R01 CA256927NCI NIH HHS U01 CA250044NIGMS NIH HHS R35 GM141832
Abstract
Tumor-derived extracellular vesicles (TEVs) suppress the proliferation and cytotoxicity of CD8
Indexed as
Immunosuppression TherapyAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesCell AdhesionCell CommunicationCell Line, TumorDisease Models, AnimalExosomesIntercellular Adhesion Molecule-1Interferon-gammaMelanomaMiceMice, Inbred C57BLNeoplasm ProteinsProtein BindingB7-H1 AntigenIntercellular Adhesion Molecule-1Interferon-gammaNeoplasm ProteinsCD8(+) T cellsexosomeextracellular vesiclesICAM-1immune suppressionPD-L1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.