Evidence map›Paper›PMID 35085412›Full record

ArticleJournal of veterinary internal medicine2022

A retrospective multi-center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia.

Yi Yu Lim, Caroline Mansfield, Mark Stevenson, Mary Thompson, David Davies, Joanna Whitney, Fleur James, Anna Tebb, Darren Fry, Sibylle Buob and 3 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
    Pooled it
  2. Article
  3. Localized fungal osteomyelitis caused byOpen veterinary journal · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Single-Dose, Intravenous, and Oral Pharmacokinetics of Isavuconazole in Dogs.Journal of veterinary pharmacology and therapeutics · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Yi Yu LimFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-7394-1782
Caroline MansfieldFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Mark StevensonAsia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Mary ThompsonSchool of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia.
David DaviesAdelaide Veterinary Specialist & Referral Centre, Adelaide, South Australia, Australia.
Joanna WhitneyFaculty of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia.
Fleur JamesPerth Veterinary Specialist, Perth, Western Australia, Australia.
Anna TebbWestern Australian Veterinary Emergency and Specialty, Perth, Western Australia, Australia.
Darren FryBrisbane Veterinary Specialist Centre, Brisbane, Queensland, Australia.
Sibylle BuobQueensland Veterinary Specialists, Brisbane, Queensland, Australia.
Lydia HambrookAdvanced Vetcare, Melbourne, Victoria, Australia.
Gladys BooEye Clinic for Animals, Sydney, New South Wales, Australia.
Julien R S DandrieuxFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-6308-8749
The University of Melbourne · AUGovernment of Western Australia · AUThe University of Sydney · AUAustralian and New Zealand Intensive Care Society · AUBrisbane School of Theology · AUEnvoi Specialist Pathologists · AUEye Care Associates · USSouth Australia Pathology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol.

objectiveTo retrospectively assess survival times and factors influencing survival times. ANIMALS: Dogs diagnosed with DA from January 2007 to June 2017.

methodsDisseminated aspergillosis case data were retrieved from 13 Australian veterinary referral centers, with a diagnosis confirmed with culture or PCR. Factors influencing survival time after diagnosis were quantified using a Cox proportional hazards regression model.

resultsThirty-four dogs met the study inclusion criteria. Twenty-two dogs were treated with antifungal treatment and 12 dogs received no antifungal treatment. Accounting for censoring of dogs that were either still alive on the date of data collection or were loss to follow-up, dogs treated with itraconazole alone (n = 8) had a median survival time (MST) of 63 (95% CI: 20-272) days compared to 830 (95% CI: 267-1259) days for the n = 14 dogs that received multimodal antifungal therapy ( CONCLUSION AND CLINICAL IMPORTANCE: Serum creatinine concentration at the time of diagnosis is a useful prognostic indicator for survival after a diagnosis of DA. The MST for dogs treated with multimodal antifungal therapy is longer than itraconazole alone and warrant further investigation (P < .01).

Indexed as

AspergillosisDog DiseasesAnimalsAustraliaDogsPrognosisRetrospective StudiesTreatment Outcomecaninemedian survival timeoutcomeprognosis

Identifiers

PMID35085412
PMCPMC8965214
OpenAlexW4210591153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.