Evidence map›Paper›PMID 35085262›Full record

ArticlePloS one

Serum progranulin is not associated with rs5848 polymorphism in Korean patients with neurodegenerative diseases.

Na-Yeon Jung, Hyang-Sook Kim, Eun Soo Kim, Sumin Jeon, Myung Jun Lee, Kyoungjune Pak, Jae-Hyeok Lee, Young Min Lee, Kangyoon Lee, Jin-Hong Shin and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Na-Yeon JungDepartment of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.ORCID https://orcid.org/0000-0002-8265-9508
Hyang-Sook KimResearch Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Eun Soo KimDepartment of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea.
Sumin JeonDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea.
Myung Jun LeeDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea.
Kyoungjune PakDepartment of Nuclear Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
Jae-Hyeok LeeDepartment of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Young Min LeeDepartment of Psychiatry, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
Kangyoon LeeDepartment of Psychiatry, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
Jin-Hong ShinDepartment of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Jun Kyeung KoDepartment of Neurosurgery, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Jae Meen LeeDepartment of Neurosurgery, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Jin A YoonDepartment of Rehabilitation Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Chungsu HwangDepartment of Pathology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Kyung-Un ChoiDepartment of Pathology, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Gi Yeong HuhDepartment of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Young-Eun KimDepartment of Laboratory Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
Eun-Joo KimDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea.
Pusan National University Hospital · KRPusan National University · KRPusan National University Yangsan Hospital · KRHanyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low serum progranulin (PGRN) is known to be associated with granulin (GRN) gene mutation and T alleles of GRN rs5848 polymorphism. However, there have been only a few Asian studies exploring these. We investigated the serum PGRN levels, rs5848 genotypes, and their relations with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in the Korean population. Serum PGRN levels, GRN rs5848 polymorphism, and GRN mutations were evaluated in 239 participants (22 cognitively unimpaired participants and 217 patients with neurodegenerative diseases). CSF AD biomarkers were also evaluated in 214 participants. There was no significant difference in the serum PGRN levels among the diagnostic groups. We could not find any GRN mutation carrier in our sample. The differences in the frequencies of the rs5848 genotypes among the clinical groups or the effects of the rs5848 genotypes on serum PGRN were not observed. There was no correlation between the serum PGRN level or rs5848 genotype and CSF AD biomarkers. Neither the T allele nor the TT genotype had an effect on the development of AD. Our results showed that serum PGRN levels were not associated with rs5848 genotypes, indicating that multiple single nucleotide polymorphisms might affect PGRN concentrations in an ethnicity-specific manner.

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overAlzheimer DiseaseBiomarkersCase-Control StudiesFemaleGenetic Association StudiesGenotyping TechniquesHumansMaleMiddle AgedMutationProgranulinsRepublic of KoreaSequence Analysis, DNABiomarkersGRN protein, humanProgranulins

Identifiers

PMID35085262
PMCPMC8794169
OpenAlexW4210793453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.