ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022
Effect of respiratory rate and size of cannula on pressure and dead-space clearance during nasal high flow in patients with COPD and acute respiratory failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review.Critical care (London, England) · 2023Pooled it
- Feasibility and safety of oxygen-free nasal high flow therapy in the acute postoperative period: a single-center randomized study.BMC anesthesiology · 2026Trial
- Trial
- Enhancing Respiratory Support in COPD Patients with Nasal High Flow Using an Asymmetrical Cannula Interface: A Randomized Cross-Over Study.International journal of chronic obstructive pulmonary disease · 2026Trial
- Efficacy of Noninvasive Ventilation With Expiratory Washout in Stable COPD Patients.Respiratory care · 2025Trial
- Respiratory support with nasal high flow without supplemental oxygen in patients undergoing endoscopic retrograde cholangiopancreatography under moderate sedation: a prospective, randomized, single-center clinical trial.BMC anesthesiology · 2023Trial
- Asymmetry from an asymmetrical cannula interface and nasogastric tube during nasal high flow enhances dead-space clearance: a fluid dynamics study.Frontiers in medicine · 2026Article
- Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.Annals of intensive care · 2026Review
- High-flow nasal cannula versus noninvasive ventilation in stabilized hypercapnic exacerbation: a physiological crossover trial.Annals of intensive care · 2026Article
- A Novel Approach to High-flow Nasal Oxygen Delivery: Physiological and Clinical Perspectives on Asymmetrical Cannulas.Thoracic research and practice · 2025Article
- Gas composition and pressure in the hypopharynx during high-flow oxygen therapy through a nasal cannula in healthy volunteers with different breathing patterns.BMC anesthesiology · 2025Article
- Digital twins suggest a mechanistic basis for differing responses to increased flow rates during high-flow nasal cannula therapy.Intensive care medicine experimental · 2025Article
- Nocturnal respiratory support with nasal high flow in hypercapnic COPD: a randomised, crossover trial.ERJ open research · 2025Article
- Physiological effects and clinical evidence of high-flow nasal cannula during acute exacerbation in COPD patients: A narrative review.Journal of intensive medicine · 2025Review
- Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: a computational study.Respiratory research · 2025Article
- The impact of different prong-nares ratio on ventilation in COPD patients using nasal high-flow (NHF) - a physiological study.BMC pulmonary medicine · 2024Article
- Effect of high-flow nasal cannula at different flow rates on diaphragmatic function in subjects recovering from an acute exacerbation of COPD: a physiological prospective pilot study.Journal of anesthesia, analgesia and critical care · 2024Article
- ERS International Congress 2023: highlights from the Respiratory Intensive Care Assembly.ERJ open research · 2024Article
- Effects of an asymmetrical high flow nasal cannula interface in hypoxemic patients.Critical care (London, England) · 2023Article
- Home High-Flow Therapy in Patients with Chronic Respiratory Diseases: Physiological Rationale and Clinical Results.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal high flow (NHF) is an efficient oxygenation tool for the treatment of respiratory failure. The study investigated the effect of breathing pattern on positive airway pressure and dead-space clearance by NHF. The breathing cycle during NHF was characterized in 26 patients with acute respiratory failure (ARF) and stable COPD and after mechanical ventilation (post-MV) via tracheostomy where also pressure was measured in the trachea. Dead-space clearance was measured in airway models during different breathing patterns. NHF reduced the respiratory rate (RR) and T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.