ArticleScience (New York, N.Y.)2022
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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28 citing papers in PubMed, 49 citations in OpenAlex.
- Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Mechanistic Target of Rapamycin and Megalencephaly: Novel Research Strategies for Therapeutic Discovery.Epilepsy currents · 2026Article
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- An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains.Nature neuroscience · 2025Article
- Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies.Neuron · 2025Review
- Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.Nature communications · 2025Article
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- OrgaCCC: Orthogonal graph autoencoders for constructing cell-cell communication networks on spatial transcriptomics data.PLoS computational biology · 2025Article
- Development of GABAergic Interneurons in the Human Cerebral Cortex.The European journal of neuroscience · 2025Review
- Fate plasticity of interneuron specification.iScience · 2025Article
- Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.Cell reports · 2025Article
- FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma.Cancer research · 2025Article
- A comparative view of human and mouse telencephalon inhibitory neuron development.Development (Cambridge, England) · 2025Review
- Pathogenesis of Germinal Matrix Hemorrhage: Insights from Single-Cell Transcriptomics.Annual review of pathology · 2025Review
- Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.Nature neuroscience · 2024Article
- GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant.Cancer cell · 2024Article
- Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons.Open biology · 2024Article
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Authors and funding
27 authors at 7 institutions in 2 countries.
Mercedes F Paredes *Department of Neurology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-2503-1447
Cristina Mora *Department of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4879-7146
Quetzal Flores-Ramirez *Department of Neurology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-0309-3428
Arantxa Cebrian-Silla *Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4623-7655
Ashley Del DossoDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Phil LarimerDepartment of Neurology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-5276-5732
Jiapei ChenBiomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-8205-8593
Gugene KangDevelopmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-2960-7434
Susana Gonzalez GraneroLaboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universitat de València-Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valencia, Spain.ORCID 0000-0003-1531-550X
Eric GarciaDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Julia ChuDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Ryan DelgadoEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-7551-0182
Jennifer A CotterDepartment of Pathology, Children's Hospital Los Angeles, and Keck School of Medicine of University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0002-1420-3314
Vivian TangDepartment of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-8829-2316
Julien SpatazzaDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
Kirsten ObernierDepartment of Neurological Surgery, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-4025-1299
Jaime Ferrer LozanoDepartment of Pathology, Hospital Universitari i Politecnic La Fe, Valencia, Spain.ORCID 0000-0001-5773-1611
Maximo VentoNeonatal Research Group, Health Research Institute La Fe, Valencia, Spain.ORCID 0000-0003-0061-4742
Julia ScottDepartment of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA.ORCID 0000-0002-8361-5259
Colin StudholmeBiomedical Image Computing Group, Departments of Pediatrics, Bioengineering, and Radiology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-8683-6906
Tomasz J NowakowskiEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
Arnold R KriegsteinDepartment of Neurology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-5742-2990
Michael C OldhamDevelopmental and Stem Cell Graduate Program, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-7633-6932
Andrea HasenstaubDepartment of Otolaryngology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-3998-5073
Jose Manuel Garcia-VerdugoLaboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universitat de València-Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Valencia, Spain.ORCID 0000-0001-9872-6499
Arturo Alvarez-BuyllaEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-4426-8925
Eric J HuangEli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-5381-3801
University of California, San Francisco · USBroad Institute · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESHospital Universitari i Politècnic La Fe · ESChildren's Hospital of Los Angeles · USSanta Clara University · USUniversity of Washington · US
Funding
Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANCY, STEPHEN PHILIP JAMES · 2014 to 2024
$12.6MNEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6MDevelopment and Expansion of the Human Cerebral CortexR35NS097305 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2017 to 2024
$8.5MNINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8MMotion Robust Mapping of Human Brain Microstructure and Macrostructure In-UteroR01NS055064 · NINDS · UNIVERSITY OF WASHINGTON · PI STUDHOLME, COLIN · 2006 to 2017
$4.1MMotion Robust Mapping of Human Brain Functional Connectivity Changes in UteroR01EB017133 · NIBIB · UNIVERSITY OF WASHINGTON · PI STUDHOLME, COLIN · 2013 to 2016
$2.5MMultiscale transcriptional architecture of the human brainR01MH123156 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDHAM, MICHAEL CLARK · 2020 to 2023
$2.4MInterneuron Precursors and the induction of cortical plasticityR01EY025174 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2015 to 2019
$2.1MMapping Developmental Lineage Relationships in the Cerebral CortexRF1MH121268 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWAKOWSKI, TOMASZ · 2019 to 2019
$2.1MDecoding the molecular basis of cellular identity in the human brainR01MH113896 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDHAM, MICHAEL CLARK · 2018 to 2022
$2.0MLate-migrating interneurons in the postnatal brainK08NS091537 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAREDES, MERCEDES · 2015 to 2019
$968kNEI NIH HHS R01 EY025174NIBIB NIH HHS R01 EB017133NIMH NIH HHS R01 MH113896NIMH NIH HHS R01 MH123156NIMH NIH HHS RF1 MH121268NINDS NIH HHS K08 NS091537NINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS028478NINDS NIH HHS R01 NS055064NINDS NIH HHS R25 NS070680NINDS NIH HHS R35 NS097305
Abstract
The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the human brain remains unclear. We found that the human MGE (hMGE) contains nests of proliferative neuroblasts with ultrastructural and transcriptomic features that distinguish them from other progenitors in the hMGE. When dissociated hMGE cells are transplanted into the neonatal mouse brain, they reform into nests containing proliferating neuroblasts that generate young neurons that migrate extensively into the mouse forebrain and mature into different subtypes of functional interneurons. Together, these results indicate that the nest organization and sustained proliferation of neuroblasts in the hMGE provide a mechanism for the extended production of interneurons for the human forebrain.
Indexed as
NeurogenesisAnimalsAnimals, NewbornCell MovementCell ProliferationCerebral CortexGABAergic NeuronsGene Expression ProfilingGestational AgeHumansInterneuronsMedian EminenceMiceNeural Stem CellsProsencephalonTransplantation, Heterologous
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