Evidence map›Paper›PMID 35084962›Full record

ArticleScience (New York, N.Y.)2022

Nitrogen recycling via gut symbionts increases in ground squirrels over the hibernation season.

Matthew D Regan, Edna Chiang, Yunxi Liu, Marco Tonelli, Kristen M Verdoorn, Sadie R Gugel, Garret Suen, Hannah V Carey, Fariba M Assadi-Porter

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 101 citations in OpenAlex.

  1. Nutrients · 2022
    Trial
  2. Review
  3. Article
  4. Article
  5. Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026
    Review
  6. Article
  7. Estivation Strategies of Invasive SnailEcology and evolution · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Host-microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Matthew D ReganDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-9341-5747
Edna ChiangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Yunxi LiuDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-5253-582X
Marco TonelliNational Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-7700-5745
Kristen M VerdoornDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sadie R GugelDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-2037-5913
Garret SuenDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-6170-711X
Hannah V CareyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-8173-0421
Fariba M Assadi-PorterDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-1761-6608
University of Wisconsin–Madison · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 1985 to 2011
$13.0M
TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4M
Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4M
NCRR NIH HHS P41 RR002301NIGMS NIH HHS P41 GM103399NIGMS NIH HHS P41 GM136463NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Hibernation is a mammalian strategy that uses metabolic plasticity to reduce energy demands and enable long-term fasting. Fasting mitigates winter food scarcity but eliminates dietary nitrogen, jeopardizing body protein balance. Here, we reveal gut microbiome-mediated urea nitrogen recycling in hibernating thirteen-lined ground squirrels (

Indexed as

HibernationAnimalsBacteriaCecumFastingFemaleGastrointestinal MicrobiomeLiverMaleNitrogenProtein BiosynthesisSciuridaeSeasonsSymbiosisUreaUreaseNitrogenUreaUrease

Identifiers

PMID35084962
PMCPMC8936132
OpenAlexW4210581642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.