Evidence map›Paper›PMID 35084938›Full record

ArticleScience (New York, N.Y.)2022

Indirect protection of children from SARS-CoV-2 infection through parental vaccination.

Samah Hayek, Galit Shaham, Yatir Ben-Shlomo, Eldad Kepten, Noa Dagan, Daniel Nevo, Marc Lipsitch, Ben Y Reis, Ran D Balicer, Noam Barda

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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  19. Human vaccines & immunotherapeutics: news February 2022.Human vaccines & immunotherapeutics · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Samah HayekClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.ORCID 0000-0002-3300-1769
Galit ShahamClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.ORCID 0000-0003-3296-8561
Yatir Ben-ShlomoClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.
Eldad KeptenClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.
Noa DaganClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.ORCID 0000-0001-8811-7825
Daniel NevoDepartment of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-9770-827X
Marc LipsitchCenter for Communicable Disease Dynamics, Department of Epidemiology, and Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-1504-9213
Ben Y ReisDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9908-5523
Ran D BalicerClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.ORCID 0000-0002-7783-6362
Noam BardaClalit Research Institute, Clalit Health Services, Ramat Gan, Israel.ORCID 0000-0002-3400-235X
Clalit Health Services · ILBen-Gurion University of the Negev · ILBoston Children's Hospital · USCenter for Disease Dynamics, Economics & Policy · USTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may still benefit from vaccines through protection from vaccinated contacts. We estimated the protection provided to children through parental vaccination with the BNT162b2 vaccine. We studied households without prior infection consisting of two parents and unvaccinated children, estimating the effect of parental vaccination on the risk of infection for unvaccinated children. We studied two periods separately-an early period (17 January 2021 to 28 March 2021; Alpha variant, two doses versus no vaccination) and a late period (11 July 2021 to 30 September 2021; Delta variant, booster dose versus two vaccine doses). We found that having a single vaccinated parent was associated with a 26.0 and a 20.8% decreased risk in the early and late periods, respectively, and having two vaccinated parents was associated with a 71.7 and a 58.1% decreased risk, respectively. Thus, parental vaccination confers substantial protection on unvaccinated children in the household.

Indexed as

BNT162 VaccineParentsAdolescentChildChild, PreschoolCOVID-19COVID-19 VaccinesFamily CharacteristicsFemaleHumansImmunization, SecondaryMaleRisk AssessmentSARS-CoV-2VaccinationBNT162 VaccineCOVID-19 Vaccines

Identifiers

PMID35084938
OpenAlexW4210591387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.