Evidence map›Paper›PMID 35084937›Full record

ArticleScience (New York, N.Y.)2022

Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel.

Ottavia Prunas, Joshua L Warren, Forrest W Crawford, Sivan Gazit, Tal Patalon, Daniel M Weinberger, Virginia E Pitzer

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. The role of children in transmission of SARS-CoV-2 variants of concern within households: an updated systematic review and meta-analysis, as at 30 June 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
  3. The role of children in household transmission of COVID-19: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Pooled it
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  8. medRxiv : the preprint server for health sciences · 2026
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  16. Lessons to Be Learned From the COVID-19 Pandemic: Some Further Ideas.International journal of public health · 2025
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ottavia PrunasDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.ORCID 0000-0003-4264-3090
Joshua L Warren *Public Health Modeling Unit, Yale School of Public Health, Yale University, New Haven, CT, USA.ORCID 0000-0002-6274-6970
Forrest W Crawford *Public Health Modeling Unit, Yale School of Public Health, Yale University, New Haven, CT, USA.ORCID 0000-0002-0046-0547
Sivan GazitMaccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.ORCID 0000-0001-9875-3550
Tal PatalonMaccabi Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.ORCID 0000-0001-7415-1053
Daniel M Weinberger *Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.ORCID 0000-0003-1178-8086
Virginia E Pitzer *Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.ORCID 0000-0003-1015-2289

Funding

Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countriesR01AI112970 · NIAID · YALE UNIVERSITY · PI PITZER, VIRGINIA E · 2015 to 2024
$4.1M
Predicting and monitoring variations in the effects of vaccines against RSVR01AI137093 · NIAID · YALE UNIVERSITY · PI Virginia E Pitzer, Daniel Martin Weinberger · 2018 to 2026
$3.4M
Network-based epidemiology for hidden and hard-to-reach populationsDP2HD091799 · NICHD · YALE UNIVERSITY · PI CRAWFORD, FORREST WRENN · 2016 to 2016
$2.5M
NIAID NIH HHS R01 AI112970NIAID NIH HHS R01 AI137093NICHD NIH HHS DP2 HD091799
6 · The paper itself

Abstract

The effectiveness of vaccines against COVID-19 on the individual level is well established. However, few studies have examined vaccine effectiveness against transmission. We used a chain binomial model to estimate the effectiveness of vaccination with BNT162b2 [Pfizer-BioNTech messenger RNA (mRNA)-based vaccine] against household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Israel before and after emergence of the B.1.617.2 (Delta) variant. Vaccination reduced susceptibility to infection by 89.4% [95% confidence interval (CI): 88.7 to 90.0%], whereas vaccine effectiveness against infectiousness given infection was 23.0% (95% CI: -11.3 to 46.7%) during days 10 to 90 after the second dose, before 1 June 2021. Total vaccine effectiveness was 91.8% (95% CI: 88.1 to 94.3%). However, vaccine effectiveness is reduced over time as a result of the combined effect of waning of immunity and emergence of the Delta variant.

Indexed as

BNT162 VaccineFamily CharacteristicsVaccine EfficacyAdolescentAdultAgedChildChild, PreschoolCOVID-19FemaleHumansInfantIsraelMaleMiddle AgedSARS-CoV-2BNT162 Vaccine

Identifiers

PMID35084937
PMCPMC9261115

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.