Evidence map›Paper›PMID 35084831›Full record

ReviewChemical reviews2022

Paramagnetic Chemical Probes for Studying Biological Macromolecules.

Qing Miao, Christoph Nitsche, Henry Orton, Mark Overhand, Gottfried Otting, Marcellus Ubbink

Abstract readReview
In one paragraph

Review in Chemical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Age-, sex-, and segment-specific myocardial T1 and T2 reference values in a healthy cohort: a prospective single-center study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Defect Tolerant Quantum Cutting in Mechanosynthesized Ytterbium-Doped Cesium Lead Chloride Perovskites.Chemistry of materials : a publication of the American Chemical Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Interaction of Cyclosporin C with DyInternational journal of molecular sciences · 2024
    Article
  15. A Spin-Labeled Derivative of Gossypol.Molecules (Basel, Switzerland) · 2024
    Article
  16. Article
  17. Review
  18. [Research progress on detection techniques for effective albumin concentration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing MiaoLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.ORCID 0000-0003-0587-1916
Christoph NitscheResearch School of Chemistry, The Australian National University, Sullivans Creek Road, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0002-3704-2699
Henry OrtonResearch School of Chemistry, The Australian National University, Sullivans Creek Road, Canberra, Australian Capital Territory 2601, Australia.
Mark OverhandLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.
Gottfried OttingResearch School of Chemistry, The Australian National University, Sullivans Creek Road, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0002-0563-0146
Marcellus UbbinkLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.ORCID 0000-0002-2615-6914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent years witnessed a great increase in the variety of probes for the study of biological macromolecules (proteins, nucleic acids, and oligosaccharides). This Review aims to provide a comprehensive overview of the existing paramagnetic chemical probes, including chemical synthetic approaches, functional properties, and selected applications. Recent developments have seen, in particular, a rapid expansion of the range of lanthanoid probes with anisotropic magnetic susceptibilities for the generation of structural restraints based on residual dipolar couplings and pseudocontact shifts in solution and solid state NMR spectroscopy, mostly for protein studies. Also many new isotropic paramagnetic probes, suitable for NMR measurements of paramagnetic relaxation enhancements, as well as EPR spectroscopic studies (in particular double resonance techniques) have been developed and employed to investigate biological macromolecules. Notwithstanding the large number of reported probes, only few have found broad application and further development of probes for dedicated applications is foreseen.

Indexed as

Nucleic AcidsProteinsElectron Spin Resonance SpectroscopyMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularOligosaccharidesNucleic AcidsOligosaccharidesProteins

Identifiers

PMID35084831
PMCPMC9136935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.