Evidence map›Paper›PMID 35084672›Full record

ArticleMolecular and cellular biochemistry2022

Permissive role of Na

Xiuju Li, Larry Fliegel

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Role of the NHE1 exchanger in the antitumor effects of copper(II) complexes and phenanthroline derivatives.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiuju LiDepartment of Biochemistry, Faculty of Medicine, University Alberta, Edmonton, AB, T6G 2H7, Canada.
Larry FliegelDepartment of Biochemistry, Faculty of Medicine, University Alberta, Edmonton, AB, T6G 2H7, Canada. lfliegel@ualberta.ca.ORCID http://orcid.org/0000-0002-8946-4850
University of Alberta · CA

Funding

cancer research Institute of northern alberta RES0050041National Science and Engineering Research Council for Canada RGPIN-2020-03932
6 · The paper itself

Abstract

In breast cancer, it is the resulting metastasis that is the primary cause of fatality. pH regulatory proteins and the tumor microenvironment play an important role in metastasis of cancer cells and acid-extruding proteins are critical in this process. There are several types of breast cancer and triple-negative breast cancer tends to be more metastatic and invasive and is itself is composed of several types. MDA-MB-468 are a triple-negative breast cancer cell line and are classified as basal-like and basal tumors account for up to 15% of breast cancers. Here we examined the effect of removal of the acid-extruding protein, the Na

Indexed as

Cell MovementFemaleHumansMCF-7 CellsNeoplasm InvasivenessNeoplasm ProteinsProtein IsoformsSodium-Hydrogen Exchanger 1Triple Negative Breast NeoplasmsNeoplasm ProteinsProtein IsoformsSLC9A1 protein, humanSodium-Hydrogen Exchanger 1Basal tumorsBreast cancerColony formationMigrationNa+/H+ exchangerpH regulation

Identifiers

PMID35084672
OpenAlexW4210586297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.