Evidence map›Paper›PMID 35084606›Full record

ArticleDigestive diseases and sciences2022

Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.

Kengyeh K Chu, Yang Zhao, Evan T Jelly, Zachary A Steelman, Michael Crose, Brian Cox, Yaa Ofori-Marfoh, Lama Moussa, Holly Cirri, Ariel Watts and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kengyeh K ChuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Yang ZhaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Evan T JellyDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Zachary A SteelmanDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Michael CroseDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Brian CoxDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Yaa Ofori-MarfohCenter for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, NC, USA.
Lama MoussaCenter for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, NC, USA.
Holly CirriCenter for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, NC, USA.
Ariel WattsCenter for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, NC, USA.
Nicholas ShaheenCenter for Esophageal Diseases and Swallowing, University of North Carolina, Chapel Hill, NC, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. A.Wax@duke.edu.ORCID 0000-0002-1827-5112
Duke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Advanced a/LCI systems for improved clinical utilityR01CA210544 · NCI · DUKE UNIVERSITY · PI SHAHEEN, NICHOLAS J, WAX, ADAM · 2017 to 2021
$2.7M
NCI NIH HHS R01 CA210544
6 · The paper itself

Abstract

BACKGROUND AND

aimsEndoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip.

methodsWe integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. We acquired images of esophageal epithelium from patients undergoing routine upper GI endoscopy. Images were classified by a reviewer blinded to patient identity and condition, and these results were compared with clinical diagnosis.

resultsWe successfully captured epithelial OCT images from 30 patients and identified features consistent with both squamous epithelium and Barrett's esophagus. Our blinded image reviewer classified BE versus non-BE with 91.5% accuracy (65/71 image regions), including sensitivity of 84.6% for BE (11/13) and a specificity of 93.1% (54/58). However, in 16 patients, intubation of the probe into the esophagus could not be achieved.

conclusionsA paddle probe is a feasible imaging format for acquiring cross-sectional OCT images from the esophagus and can provide a structural assessment of BE and non-BE tissue. Probe form factor is the current limiting obstacle, but could be addressed by further miniaturization.

Indexed as

Barrett EsophagusEsophageal NeoplasmsEndoscopesEndoscopy, Digestive SystemEsophagoscopyHumansTomography, Optical CoherenceBarrett’s esophagusImagingNew technologyOptical coherence tomography

Identifiers

PMID35084606
PMCPMC10015416
OpenAlexW4210335011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.