Evidence map›Paper›PMID 35084584›Full record

ArticleOral and maxillofacial surgery2023

Outcome of healing after dental implant placement in patients with cancer on high-dose antiresorptive medications: a prospective feasibility study.

Sanne Werner Møller Andersen, Camilla Ottesen, Klaus Gotfredsen, Simon Storgård Jensen, Thomas Kofod, Morten Schiodt

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Oral and maxillofacial surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04741906 (Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04741906 recruitingnot on this map

Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication

Typeobservational_patient_registrySponsorCopenhagen University Hospital at HerlevRan2017 to 2025Enrolled225ConditionsMissing Teeth, Implants, Cancer, OsteoporosisArmsDental implant surgery, Prosthetic treatment
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sanne Werner Møller AndersenDepartment of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. sanne.werner.moeller.andersen@regionh.dk.ORCID http://orcid.org/0000-0001-9016-2895
Camilla OttesenDepartment of Oral Rehabilitation, School of Dentistry, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0003-2587-8672
Klaus GotfredsenDepartment of Oral Rehabilitation, School of Dentistry, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Alle 20, 2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0003-1444-9362
Simon Storgård JensenDepartment of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3519-4103
Thomas KofodDepartment of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2445-6451
Morten SchiodtDepartment of Oral & Maxillofacial Surgery, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImplant placement in patients with cancer receiving high-dose antiresorptive medication (HDAR) is considered contraindicated. This prospective, feasibility study tested the hypothesis that dental implants can be placed in such patients by applying a staged implant placement protocol with submerged healing.

methodsThree groups of patients on HDAR were included as follows: group 1: patients who underwent tooth extraction, without the development of medication-related osteonecrosis of the jaws (MRONJ); group 2: patients with surgically treated MRONJ who had demonstrated clinical healing for at least 3 months; group 3: patients with established MRONJ who was planned for surgical resection and simultaneous implant placement.

resultsA total of 49 implants were placed in 27 patients (group 1: 12, group 2: 7 and group 3: 8). HDAR included bisphosphonates and denosumab. The mean HDAR time was 25 months (SD: ± 18.4, range 3-68 months). An abutment operation was performed 4 months following the implant placement (SD: ± 1.9, range 3-14 months). All patients healed uneventfully.

conclusionsThis study demonstrated that it is feasible to insert dental implants and perform an abutment surgery in patients with cancer on HDAR, without the development of MRONJ.

trial registrationCLINICALTRIALS: gov Identifier: NCT04741906.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsDental ImplantsNeoplasmsFeasibility StudiesHumansProspective StudiesBone Density Conservation AgentsDental ImplantsAntiresorptive agentsCancerDental implantProsthodontics

Identifiers

PMID35084584
OpenAlexW4210373265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.