Trial reportLangenbeck's archives of surgery2022
Prehabilitation in patients undergoing colorectal surgery fails to confer reduction in overall morbidity: results of a single-center, blinded, randomized controlled trial.
Trial report in Langenbeck's archives of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02746731 (Randomized Controlled Trial Assessing the Value of Prehabilitation in Patients Undergoing Colorectal Surgery According to the ERAS Protocol for the Improvement of Postoperative Outcomes), which is not on this map. Cited by 25 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial Assessing the Value of Prehabilitation in Patients Undergoing Colorectal Surgery According to the ERAS Protocol for the Improvement of Postoperative Outcomes
Who cites it
25 citing papers in PubMed, 10 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Effectiveness of prehabilitation for patients with colorectal surgery: a systematic review and network meta-analysis.Updates in surgery · 2026Pooled it
- Rationales for Prehabilitation Programs in Patients Preparing for Oncologic Surgery: A Systematic Review.Annals of surgical oncology · 2026Pooled it
- Evaluating the therapeutic quality of prehabilitation programmes in patients scheduled for colorectal surgery: A systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- The 2024 Korean Enhanced Recovery After Surgery (ERAS) guidelines for colorectal cancer: a secondary publication.Annals of coloproctology · 2025Guideline
- Effects of different prehabilitation programs on the major abdominal surgery population: a systematic review and network meta-analysis.Frontiers in medicine · 2025Pooled it
- Physical Prehabilitation in Patients who Underwent Major Abdominal Surgery: A Comprehensive Systematic Review and Component Network Meta-Analysis Using GRADE and CINeMA Approach.Annals of surgical oncology · 2024Pooled it
- Prehabilitation programs for individuals with cancer: a systematic review of randomized-controlled trials.Systematic reviews · 2023Pooled it
- Impact of preoperative uni- or multimodal prehabilitation on postoperative morbidity: meta-analysis.BJS open · 2023Pooled it
- Cost-effectiveness of prehabilitation prior to elective surgery: a systematic review of economic evaluations.BMC medicine · 2023Pooled it
- Effect of Preoperative Lifestyle Management and Prehabilitation on Postoperative Capability of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis.Integrative cancer therapiesPooled it
- Impact of Mobilization Facilitated by Wearable Device Enhanced Patient Monitoring/Electrophysiology Pod-Based Feedback on Postoperative Complications Following Colorectal Cancer Surgery: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- The effects of psychological intervention on negative emotions, pain, and sleep in patients with advanced colon cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Trial
- Trial
- Preliminary Outcomes of a Digital Remote Care Solution for Colorectal Cancer Patients.Cancers · 2025Article
- Multimodal Prehabilitation in Major Abdominal Surgery-Rationale, Modalities, Results and Limitations.Medicina (Kaunas, Lithuania) · 2025Review
- Review
- Risk factors for non-clinical prolonged lengths of stay after elective colorectal surgery.Scientific reports · 2025Article
- Towards a common definition of surgical prehabilitation: a scoping review of randomised trials.British journal of anaesthesia · 2024Article
- Outcomes reported in randomised trials of surgical prehabilitation: a scoping review.British journal of anaesthesia · 2024Article
- Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.Hepatobiliary surgery and nutrition · 2024Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, there are solely weak recommendations in the enhanced recovery after surgery (ERAS) protocol regarding the role of preoperative physical activity and prehabilitation in patients undergoing colorectal surgery. Studies in heterogenous groups showed contradictory results regarding the impact of prehabilitation on the reduction of postoperative complications. The aim of this study was to assess the impact of prehabilitation on postoperative complications in patients undergoing colorectal surgery within an ERAS protocol.
methodsBetween July 2016 and June 2019, a single-center, blinded, randomized controlled trial designed to test whether physiotherapeutic prehabilitation vs. normal physical activities prior to colorectal surgery may decrease morbidity within a stringent ERAS protocol was carried out. The primary endpoint was postoperative complications assessed by Comprehensive Complications Index (CCI®). Primary and secondary endpoints for both groups were analyzed and compared.
resultsA total of 107 patients (54 in the prehabilitation enhanced recovery after colorectal surgery [pERACS] group and 53 in the control group) were included in the study and randomized. Dropout rate was 4.5% (n = 5). Baseline characteristics were comparable between the pERACS and control groups. The percentage of colorectal adenocarcinoma was low in both groups (pERACS 32% vs. control 23%, p = 0.384). Almost all patients underwent minimally invasive surgery in both groups (96% vs. 98%, p = 1.000). There was no between-group difference in the primary outcome, as the mean CCI at 30-day postoperative in the pERACS group was 18 (SD 0-43) compared to 15 (SD 0-49) in the control group (p = 0.059). Secondary outcome as complications assessed according to Clavien-Dindo, length of hospital stay, reoperation rate, and mortality showed no difference between both groups.
conclusionsRoutine physiotherapeutic prehabilitation has no additional benefit for patients undergoing colorectal surgery within an ERAS protocol.
trial registrationClinicalTrial.gov: ID: NCT02746731; Institution Ethical Board Approval: KEK-ZH Nr. 2016-00,229.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.